Selective reduction of carboxylic acids to aldehydes catalyzed by B(C 6F5)3

David Bézier, Sehoon Park, Maurice Brookhart*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

B(C6F5)3 efficiently catalyzes hydrosilylation of aliphatic and aromatic carboxylic acids to produce disilyl acetals under mild conditions. Catalyst loadings can be as low as 0.05 mol %, and bulky tertiary silanes are favored to give selectively the acetals. Acidic workup of the disilyl acetals results in the formation of aldehydes in good to excellent yields.

Original languageEnglish
Pages (from-to)496-499
Number of pages4
JournalOrganic Letters
Volume15
Issue number3
DOIs
StatePublished - 1 Feb 2013
Externally publishedYes

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