Abstract
Two novel approaches for modelling processes that can be described by a sequence of phases (metabolic states) are suggested and applied to Escherichia Coli fermentations. The first approach uses a multi-compartment model framework, coupled with knowledge-based logic. In X the second approach the multi-compartment model is reduced into the Variable Structure Model consisting of a battery of alternative submodels, each of which qualitatively represents one of the process steps. Furthermore, simulated intracellular process variables are compared with the output of a multi-wavelength fluorosensor and excitation-emission pairs that predict best these variables are identified.
Original language | English |
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Pages (from-to) | 323-329 |
Number of pages | 7 |
Journal | Bioprocess Engineering |
Volume | 16 |
Issue number | 6 |
DOIs | |
State | Published - 1997 |
Externally published | Yes |