Integration of gold nanoparticles into bilayer structures via adaptive surface chemistry

Hee Young Lee; Sun Hae Ra Shin; Ludmila L. Abezgauz; Sean A. Lewis; Aaron M. Chirsan; Dganit D. Danino; Kyle J.M. Bishop

doi:10.1021/ja400225n

Integration of gold nanoparticles into bilayer structures via adaptive surface chemistry

Hee Young Lee, Sun Hae Ra Shin, Ludmila L. Abezgauz, Sean A. Lewis, Aaron M. Chirsan, Dganit D. Danino, Kyle J.M. Bishop^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

We describe the spontaneous incorporation of amphiphilic gold nanoparticles (Au NPs) into the walls of surfactant vesicles. Au NPs were functionalized with mixed monolayers of hydrophilic (deprotonated mercaptoundecanoic acid, MUA) and hydrophobic (octadecanethiol, ODT) ligands, which are known to redistribute dynamically on the NP surface in response to changes in the local environment. When Au NPs are mixed with preformed surfactant vesicles, the hydrophobic ODT ligands on the NP surface interact favorably with the hydrophobic core of the bilayer structure and guide the incorporation of NPs into the vesicle walls. Unlike previous strategies based on small hydrophobic NPs, the present approach allows for the incorporation of water-soluble particles even when the size of the particles greatly exceeds the bilayer thickness. The strategy described here based on inorganic NPs functionalized with two labile ligands should in principle be applicable to other nanoparticle materials and bilayer structures.

Original language	English
Pages (from-to)	5950-5953
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	135
Issue number	16
DOIs	https://doi.org/10.1021/ja400225n
State	Published - 24 Apr 2013
Externally published	Yes

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title = "Integration of gold nanoparticles into bilayer structures via adaptive surface chemistry",

abstract = "We describe the spontaneous incorporation of amphiphilic gold nanoparticles (Au NPs) into the walls of surfactant vesicles. Au NPs were functionalized with mixed monolayers of hydrophilic (deprotonated mercaptoundecanoic acid, MUA) and hydrophobic (octadecanethiol, ODT) ligands, which are known to redistribute dynamically on the NP surface in response to changes in the local environment. When Au NPs are mixed with preformed surfactant vesicles, the hydrophobic ODT ligands on the NP surface interact favorably with the hydrophobic core of the bilayer structure and guide the incorporation of NPs into the vesicle walls. Unlike previous strategies based on small hydrophobic NPs, the present approach allows for the incorporation of water-soluble particles even when the size of the particles greatly exceeds the bilayer thickness. The strategy described here based on inorganic NPs functionalized with two labile ligands should in principle be applicable to other nanoparticle materials and bilayer structures.",

author = "Lee, {Hee Young} and Shin, {Sun Hae Ra} and Abezgauz, {Ludmila L.} and Lewis, {Sean A.} and Chirsan, {Aaron M.} and Danino, {Dganit D.} and Bishop, {Kyle J.M.}",

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T1 - Integration of gold nanoparticles into bilayer structures via adaptive surface chemistry

AU - Lee, Hee Young

AU - Shin, Sun Hae Ra

AU - Abezgauz, Ludmila L.

AU - Lewis, Sean A.

AU - Chirsan, Aaron M.

AU - Danino, Dganit D.

AU - Bishop, Kyle J.M.

PY - 2013/4/24

Y1 - 2013/4/24

N2 - We describe the spontaneous incorporation of amphiphilic gold nanoparticles (Au NPs) into the walls of surfactant vesicles. Au NPs were functionalized with mixed monolayers of hydrophilic (deprotonated mercaptoundecanoic acid, MUA) and hydrophobic (octadecanethiol, ODT) ligands, which are known to redistribute dynamically on the NP surface in response to changes in the local environment. When Au NPs are mixed with preformed surfactant vesicles, the hydrophobic ODT ligands on the NP surface interact favorably with the hydrophobic core of the bilayer structure and guide the incorporation of NPs into the vesicle walls. Unlike previous strategies based on small hydrophobic NPs, the present approach allows for the incorporation of water-soluble particles even when the size of the particles greatly exceeds the bilayer thickness. The strategy described here based on inorganic NPs functionalized with two labile ligands should in principle be applicable to other nanoparticle materials and bilayer structures.

AB - We describe the spontaneous incorporation of amphiphilic gold nanoparticles (Au NPs) into the walls of surfactant vesicles. Au NPs were functionalized with mixed monolayers of hydrophilic (deprotonated mercaptoundecanoic acid, MUA) and hydrophobic (octadecanethiol, ODT) ligands, which are known to redistribute dynamically on the NP surface in response to changes in the local environment. When Au NPs are mixed with preformed surfactant vesicles, the hydrophobic ODT ligands on the NP surface interact favorably with the hydrophobic core of the bilayer structure and guide the incorporation of NPs into the vesicle walls. Unlike previous strategies based on small hydrophobic NPs, the present approach allows for the incorporation of water-soluble particles even when the size of the particles greatly exceeds the bilayer thickness. The strategy described here based on inorganic NPs functionalized with two labile ligands should in principle be applicable to other nanoparticle materials and bilayer structures.

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JF - Journal of the American Chemical Society

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Integration of gold nanoparticles into bilayer structures via adaptive surface chemistry

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