Catalytic regeneration of a Th-H bond from a Th-O bond through a mild and chemoselective carbonyl hydroboration

Tapas Ghatak, Konstantin Makarov, Natalia Fridman, Moris S. Eisen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Here we present an unprecedented chemoselective hydroboration for aldehydes and ketones catalysed by actinides. The reaction features a very low catalyst loading (0.1-0.004 mol%) and quantitative product formation in less than 15 minutes, at room temperature. Thermodynamic and kinetic studies including stoichiometric and labeling studies with deuterated pinacolborane allow us to propose a plausible mechanism for this remarkable catalytic regeneration of a Th-H bond via carbonyl hydroboration.

Original languageEnglish
Pages (from-to)11001-11004
Number of pages4
JournalChemical Communications
Volume54
Issue number78
DOIs
StatePublished - 2018
Externally publishedYes

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