TY - JOUR
T1 - Type VI secretion regulation
T2 - Crosstalk and intracellular communication
AU - Leung, Ka Yin
AU - Siame, Bupe A.
AU - Snowball, Heather
AU - Mok, Yu Keung
N1 - Funding Information:
Our thanks go to Drs. Jun Zheng, Hong Bing Yu, and Ilan Rosenshine for critically reviewing the manuscript. Work in the authors’ laboratories was supported by a Natural Science and Engineering Research Council (NSERC) Discovery Grant ( 372373-2010 ) and a Trinity Western University Startup Grant ( 0488 ) to K.Y.L., a Biomedical Research Council (BMRC) grant from the Agency for Science Technology and Research (A*STAR), Singapore to Y.K.M. (07/1/21/19/495).
PY - 2011/2
Y1 - 2011/2
N2 - Pathogens use type VI secretion systems (T6SSs) to transport proteins into the environment or host cells in response to external stimuli. T6SSs are tightly regulated together with other virulence determinants such as type III secretion systems, quorum sensing (QS), and flagella synthesis. Five pathogens (Salmonella enterica, Edwardsiella tarda, Aeromonas hydrophila, Vibrio cholerae, and Pseudomonas aeruginosa) are examined for crosstalk proteins (global regulators) that connect T6SSs to other virulence determinants. Common transcriptional regulators (TRs) include two component systems (i.e. PhoPQ), σ54 and σ54-dependent TRs (i.e. VasH), and QS regulators. Greater understanding of this integral communication network will define what is essential for bacterial pathogenesis.
AB - Pathogens use type VI secretion systems (T6SSs) to transport proteins into the environment or host cells in response to external stimuli. T6SSs are tightly regulated together with other virulence determinants such as type III secretion systems, quorum sensing (QS), and flagella synthesis. Five pathogens (Salmonella enterica, Edwardsiella tarda, Aeromonas hydrophila, Vibrio cholerae, and Pseudomonas aeruginosa) are examined for crosstalk proteins (global regulators) that connect T6SSs to other virulence determinants. Common transcriptional regulators (TRs) include two component systems (i.e. PhoPQ), σ54 and σ54-dependent TRs (i.e. VasH), and QS regulators. Greater understanding of this integral communication network will define what is essential for bacterial pathogenesis.
UR - http://www.scopus.com/inward/record.url?scp=79551688546&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2010.09.017
DO - 10.1016/j.mib.2010.09.017
M3 - 文献综述
C2 - 20971679
AN - SCOPUS:79551688546
SN - 1369-5274
VL - 14
SP - 9
EP - 15
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 1
ER -