Synthesis of 2-[2H]-2-(1-methylalkyl)succinic acids

Xin Yu Bian, Serge Maurice Mbadinga, Shi Zhong Yang, Ru Qiang Ye, Ji Dong Gu, Bo Zhong Mu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We describe a specific procedure for the synthesis of deuterium-labelled 2-(1-methylalkyl)succinate established via alkylation of diethyl malonate, Krapcho decarboxylation reaction with D2O and hydrolysis reaction. Two novel compounds, 2-[2H]-2-ethylsuccinic acid and 2-[2H]-2-(1-methylheptyl)succinic acid were prepared via this synthetic route and characterized by mass spectrometry and 1H NMR. The results showed that the 2-(1-methylalkyl)succinic acids were deuterated at the β-position, which is considered as an important reaction centre in the anaerobic degradation of n-alkanes.

Original languageEnglish
Pages (from-to)619-622
Number of pages4
JournalChinese Chemical Letters
Issue number5
StatePublished - 1 May 2015
Externally publishedYes


  • 2-(1-Methylalkyl)succinates
  • Anaerobic degradation of alkanes
  • Deuterium-labelled biomarkers
  • Fumarate addition


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