Spontaneous alternating copolymer vesicles of alkylmaleimides and vinyl gluconamide

Stephen G. Fenimore; Ludmila Abezgauz; Dganit Danino; Chia Chi Ho; Carlos C. Co

doi:10.1021/ma802472j

Spontaneous alternating copolymer vesicles of alkylmaleimides and vinyl gluconamide

Stephen G. Fenimore, Ludmila Abezgauz, Dganit Danino, Chia Chi Ho, Carlos C. Co

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Alternating copolymers of N-n-alkylmaleimides and vinyl gluconamide spontaneously form ultrasmall-and medium-sized (10-20and50-300 nm, respectively) vesicles when dissolved in water at room temperature. These materials have molecular weights that are approximately 100 times higher than those of previously reported alternating oligomers of alkylmaleate and vinyl ether monomers and conclusively demonstrate that alternating copolymers can form vesicles. The size and shape of the vesicles are thoroughly characterized by cryogenic transmission electron microscopy (cryo-TEM), dynamic light scattering (DLS), and small-angle neutron scattering (SANS). The copolymer vesicles exhibit alkyl-chain-length-dependent release characteristics and bilayer thickness (1.7, 2.0, and 2.6 nm for alkyl chains of 10, 12, and 14 carbons, respectively).

Original language	English
Pages (from-to)	2702-2707
Number of pages	6
Journal	Macromolecules
Volume	42
Issue number	7
DOIs	https://doi.org/10.1021/ma802472j
State	Published - 14 Apr 2009
Externally published	Yes

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title = "Spontaneous alternating copolymer vesicles of alkylmaleimides and vinyl gluconamide",

abstract = "Alternating copolymers of N-n-alkylmaleimides and vinyl gluconamide spontaneously form ultrasmall-and medium-sized (10-20and50-300 nm, respectively) vesicles when dissolved in water at room temperature. These materials have molecular weights that are approximately 100 times higher than those of previously reported alternating oligomers of alkylmaleate and vinyl ether monomers and conclusively demonstrate that alternating copolymers can form vesicles. The size and shape of the vesicles are thoroughly characterized by cryogenic transmission electron microscopy (cryo-TEM), dynamic light scattering (DLS), and small-angle neutron scattering (SANS). The copolymer vesicles exhibit alkyl-chain-length-dependent release characteristics and bilayer thickness (1.7, 2.0, and 2.6 nm for alkyl chains of 10, 12, and 14 carbons, respectively).",

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doi = "10.1021/ma802472j",

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T1 - Spontaneous alternating copolymer vesicles of alkylmaleimides and vinyl gluconamide

AU - Fenimore, Stephen G.

AU - Abezgauz, Ludmila

AU - Danino, Dganit

AU - Ho, Chia Chi

AU - Co, Carlos C.

PY - 2009/4/14

Y1 - 2009/4/14

N2 - Alternating copolymers of N-n-alkylmaleimides and vinyl gluconamide spontaneously form ultrasmall-and medium-sized (10-20and50-300 nm, respectively) vesicles when dissolved in water at room temperature. These materials have molecular weights that are approximately 100 times higher than those of previously reported alternating oligomers of alkylmaleate and vinyl ether monomers and conclusively demonstrate that alternating copolymers can form vesicles. The size and shape of the vesicles are thoroughly characterized by cryogenic transmission electron microscopy (cryo-TEM), dynamic light scattering (DLS), and small-angle neutron scattering (SANS). The copolymer vesicles exhibit alkyl-chain-length-dependent release characteristics and bilayer thickness (1.7, 2.0, and 2.6 nm for alkyl chains of 10, 12, and 14 carbons, respectively).

AB - Alternating copolymers of N-n-alkylmaleimides and vinyl gluconamide spontaneously form ultrasmall-and medium-sized (10-20and50-300 nm, respectively) vesicles when dissolved in water at room temperature. These materials have molecular weights that are approximately 100 times higher than those of previously reported alternating oligomers of alkylmaleate and vinyl ether monomers and conclusively demonstrate that alternating copolymers can form vesicles. The size and shape of the vesicles are thoroughly characterized by cryogenic transmission electron microscopy (cryo-TEM), dynamic light scattering (DLS), and small-angle neutron scattering (SANS). The copolymer vesicles exhibit alkyl-chain-length-dependent release characteristics and bilayer thickness (1.7, 2.0, and 2.6 nm for alkyl chains of 10, 12, and 14 carbons, respectively).

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Spontaneous alternating copolymer vesicles of alkylmaleimides and vinyl gluconamide

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