Sonochemical stabilization of ultrafine colloidal biocompatible magnetite nanoparticles using amino acid, l-arginine, for possible bio applications

TY - JOUR

T1 - Sonochemical stabilization of ultrafine colloidal biocompatible magnetite nanoparticles using amino acid, l-arginine, for possible bio applications

AU - Theerdhala, Sriharsha

AU - Bahadur, Dhirendra

AU - Vitta, Satish

AU - Perkas, Nina

AU - Zhong, Ziyi

AU - Gedanken, Aharon

PY - 2010/4

Y1 - 2010/4

N2 - Materials obtained by the synergistic combination of nanotechnology and biomedicine are an important source of drug delivery and other health care related applications. The anchoring of amino acids onto the surface of nano-sized magnetite is one such example. Herein, we report on the binding of a semi-essential amino acid, l-arginine, onto the surface of nano magnetite, creating a stable aqueous suspension by an in situ one-step method using sonochemical synthesis. An ex situ two-step process was also attempted, but was soon discarded owing to the relative short duration of the suspension attributed to increase in particle size and lower extent of binding. The initial concentration of the amino acid was found to play an important role in controlling the particle size and also the binding motif. Lower concentrations of arginine were found to favor the formation of elongated tubular structures, while at higher concentrations, the elongated structures were less prominent and arginine was found to be adsorbed onto the surface of the magnetite. This surface-functionalized nanomagnetite with amino acids could become a promising vehicle for drug delivery.

AB - Materials obtained by the synergistic combination of nanotechnology and biomedicine are an important source of drug delivery and other health care related applications. The anchoring of amino acids onto the surface of nano-sized magnetite is one such example. Herein, we report on the binding of a semi-essential amino acid, l-arginine, onto the surface of nano magnetite, creating a stable aqueous suspension by an in situ one-step method using sonochemical synthesis. An ex situ two-step process was also attempted, but was soon discarded owing to the relative short duration of the suspension attributed to increase in particle size and lower extent of binding. The initial concentration of the amino acid was found to play an important role in controlling the particle size and also the binding motif. Lower concentrations of arginine were found to favor the formation of elongated tubular structures, while at higher concentrations, the elongated structures were less prominent and arginine was found to be adsorbed onto the surface of the magnetite. This surface-functionalized nanomagnetite with amino acids could become a promising vehicle for drug delivery.

KW - Amino acid

KW - Drug delivery

KW - Magnetite

KW - Sonochemistry

KW - Stable colloidal solution

UR - http://www.scopus.com/inward/record.url?scp=77649273917&partnerID=8YFLogxK

U2 - 10.1016/j.ultsonch.2009.12.007

DO - 10.1016/j.ultsonch.2009.12.007

M3 - 文章

C2 - 20042358

AN - SCOPUS:77649273917

SN - 1350-4177

VL - 17

SP - 730

EP - 737

JO - Ultrasonics Sonochemistry

JF - Ultrasonics Sonochemistry

IS - 4

ER -