Role of proton balance in formation of self-assembled chitosan nanoparticles

Anomitra Dey, Aditya Kamat, Sonal Nayak, Dganit Danino, Ellina Kesselman, Prajakta Dandekar*, Ratnesh Jain

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Researchers have explored the ability of chitosan to form nanoparticles, to suit varying applications, ranging from wound-healing to gene delivery. Ionic gelation is a widely used method for formulating chitosan nanoparticles, where self-assembly plays a crucial role. This self-assembly is initially promoted by hydrophilic-hydrophobic parity amongst individual chitosan residues, along with electrostatic and Van der Waals interactions with the cross-linker. However, until now the intrinsic ability of chitosan to self-assemble is not widely studied; hence, we investigate the self-assembly of chitosan, based on proton balance between its protonated and deprotonated residues, to promote facile nanoparticle synthesis. This is one of the first reports that highlights subtle but critical influence of proton balance in the chitosan polymer on the formation of chitosan nanoparticles.

Original languageEnglish
Pages (from-to)127-134
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
StatePublished - 1 Jun 2018
Externally publishedYes


  • Chitosan nanoparticles
  • Docking
  • Protonation
  • Self-assembly
  • Umbrella sampling


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