Role of proton balance in formation of self-assembled chitosan nanoparticles

Anomitra Dey; Aditya Kamat; Sonal Nayak; Dganit Danino; Ellina Kesselman; Prajakta Dandekar; Ratnesh Jain

doi:10.1016/j.colsurfb.2018.03.017

Role of proton balance in formation of self-assembled chitosan nanoparticles

Anomitra Dey, Aditya Kamat, Sonal Nayak, Dganit Danino, Ellina Kesselman, Prajakta Dandekar^*, Ratnesh Jain

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Researchers have explored the ability of chitosan to form nanoparticles, to suit varying applications, ranging from wound-healing to gene delivery. Ionic gelation is a widely used method for formulating chitosan nanoparticles, where self-assembly plays a crucial role. This self-assembly is initially promoted by hydrophilic-hydrophobic parity amongst individual chitosan residues, along with electrostatic and Van der Waals interactions with the cross-linker. However, until now the intrinsic ability of chitosan to self-assemble is not widely studied; hence, we investigate the self-assembly of chitosan, based on proton balance between its protonated and deprotonated residues, to promote facile nanoparticle synthesis. This is one of the first reports that highlights subtle but critical influence of proton balance in the chitosan polymer on the formation of chitosan nanoparticles.

Original language	English
Pages (from-to)	127-134
Number of pages	8
Journal	Colloids and Surfaces B: Biointerfaces
Volume	166
DOIs	https://doi.org/10.1016/j.colsurfb.2018.03.017
State	Published - 1 Jun 2018
Externally published	Yes

Keywords

Chitosan nanoparticles
Docking
Protonation
Self-assembly
Umbrella sampling

Access to Document

10.1016/j.colsurfb.2018.03.017

Cite this

@article{bdf3f9833f0f4ab69dbcc88a312cda35,

title = "Role of proton balance in formation of self-assembled chitosan nanoparticles",

abstract = "Researchers have explored the ability of chitosan to form nanoparticles, to suit varying applications, ranging from wound-healing to gene delivery. Ionic gelation is a widely used method for formulating chitosan nanoparticles, where self-assembly plays a crucial role. This self-assembly is initially promoted by hydrophilic-hydrophobic parity amongst individual chitosan residues, along with electrostatic and Van der Waals interactions with the cross-linker. However, until now the intrinsic ability of chitosan to self-assemble is not widely studied; hence, we investigate the self-assembly of chitosan, based on proton balance between its protonated and deprotonated residues, to promote facile nanoparticle synthesis. This is one of the first reports that highlights subtle but critical influence of proton balance in the chitosan polymer on the formation of chitosan nanoparticles.",

keywords = "Chitosan nanoparticles, Docking, Protonation, Self-assembly, Umbrella sampling",

author = "Anomitra Dey and Aditya Kamat and Sonal Nayak and Dganit Danino and Ellina Kesselman and Prajakta Dandekar and Ratnesh Jain",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2018",

month = jun,

day = "1",

doi = "10.1016/j.colsurfb.2018.03.017",

language = "英语",

volume = "166",

pages = "127--134",

journal = "Colloids and Surfaces B: Biointerfaces",

issn = "0927-7765",

publisher = "Elsevier",

}

TY - JOUR

T1 - Role of proton balance in formation of self-assembled chitosan nanoparticles

AU - Dey, Anomitra

AU - Kamat, Aditya

AU - Nayak, Sonal

AU - Danino, Dganit

AU - Kesselman, Ellina

AU - Dandekar, Prajakta

AU - Jain, Ratnesh

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Researchers have explored the ability of chitosan to form nanoparticles, to suit varying applications, ranging from wound-healing to gene delivery. Ionic gelation is a widely used method for formulating chitosan nanoparticles, where self-assembly plays a crucial role. This self-assembly is initially promoted by hydrophilic-hydrophobic parity amongst individual chitosan residues, along with electrostatic and Van der Waals interactions with the cross-linker. However, until now the intrinsic ability of chitosan to self-assemble is not widely studied; hence, we investigate the self-assembly of chitosan, based on proton balance between its protonated and deprotonated residues, to promote facile nanoparticle synthesis. This is one of the first reports that highlights subtle but critical influence of proton balance in the chitosan polymer on the formation of chitosan nanoparticles.

AB - Researchers have explored the ability of chitosan to form nanoparticles, to suit varying applications, ranging from wound-healing to gene delivery. Ionic gelation is a widely used method for formulating chitosan nanoparticles, where self-assembly plays a crucial role. This self-assembly is initially promoted by hydrophilic-hydrophobic parity amongst individual chitosan residues, along with electrostatic and Van der Waals interactions with the cross-linker. However, until now the intrinsic ability of chitosan to self-assemble is not widely studied; hence, we investigate the self-assembly of chitosan, based on proton balance between its protonated and deprotonated residues, to promote facile nanoparticle synthesis. This is one of the first reports that highlights subtle but critical influence of proton balance in the chitosan polymer on the formation of chitosan nanoparticles.

KW - Chitosan nanoparticles

KW - Docking

KW - Protonation

KW - Self-assembly

KW - Umbrella sampling

UR - http://www.scopus.com/inward/record.url?scp=85043767240&partnerID=8YFLogxK

U2 - 10.1016/j.colsurfb.2018.03.017

DO - 10.1016/j.colsurfb.2018.03.017

M3 - 文章

C2 - 29558703

AN - SCOPUS:85043767240

SN - 0927-7765

VL - 166

SP - 127

EP - 134

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

ER -

Role of proton balance in formation of self-assembled chitosan nanoparticles

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this