Research progress on the antibacterial mechanismsofcarvacrol: A mini review

Dan Zhang, Ren You Gan*, Ying Ying Ge, Qiong Qiong Yang, Jiao Ge, Hua Bin Li, Harold Corke

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Background: Carvacrol is an aromatic phenolicterpenoidwidely existingin the volatile oils of thyme, oregano, and some other aromatic plants. Recent studies have found that carvacrol possessesexcellent antibacterial activity. Thus, inorder to provide an updated information about the antibacterial potentials of carvacrolwe summarized recent publications about the antibacterial activity of carvacrol,with special attention paid to its antibacterial molecular mechanisms, includingdisruptingcellmembrane, depleting intracellular ATP, inducing reactive oxygen species, inhibiting efflux pumps, as well as suppressing two important virulence factors:biofilm and quorum sensing.In conclusion, carvacrol is a promising natural antibacterial compound with potential application in food preservation and infection.

Original languageEnglish
Pages (from-to)71-81
Number of pages11
JournalBioactive Compounds in Health and Disease
Issue number6
StatePublished - Oct 2018
Externally publishedYes


  • Antibacterialmechanisms
  • Biofilm
  • Carvacrol
  • Quorum sensing


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