Recent advances and perspectives on the biomass-derived production of the platform chemical triacetic acid lactone by engineered cell factories

Yangming Liu; Yuhan Jin; Peng Xu; Li Deng; Huan Liu; Fang Wang

doi:10.1016/j.bej.2023.108961

Recent advances and perspectives on the biomass-derived production of the platform chemical triacetic acid lactone by engineered cell factories

Yangming Liu, Yuhan Jin, Peng Xu^*, Li Deng^*, Huan Liu^*, Fang Wang

^*Corresponding author for this work

Chemical Engineering

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

As an important platform chemical, triacetic acid lactone (TAL) is considered the “bridge” molecule between biotransformation and chemical catalysis. The conventional production methods relying on plant extraction and chemical conversion restricted its large-scale application due to limited natural resources and serious environmental concerns. The conversion of low-cost biomass-derived carbohydrates into platform molecules by engineered microbes provides a promising alternative to produce a variety of end products with commercial values. In this review, we summarized the research progress of TAL biomanufacturing via biological approach by the metabolically engineered cell factories, including the construction of efficient biosynthetic pathways in different hosts, the development and pretreatment of biomass and industrial waste as feedstocks, and the establishment of the novel biosensor to enhance TAL synthesis. Despite the biosynthesis of TAL successfully achieved by these strategies, there are still great challenges to making the biomanufacturing of TAL economically viable. Some issues in the bio-production of TAL were discussed and potential strategies to improve the techno-economic feasibility were proposed in this review. It was hoped that these views could help to provide more rational and feasible ways for cost-efficient manufacturing of TAL by engineered microbes.

Original language	English
Article number	108961
Journal	Biochemical Engineering Journal
Volume	197
Early online date	3 May 2023
DOIs	https://doi.org/10.1016/j.bej.2023.108961 https://doi.org/10.1016/j.bej.2023.108961
State	Published - Aug 2023

Keywords

Biosensor
Lignocellulose
Metabolic engineering
Triacetic acid lactone

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title = "Recent advances and perspectives on the biomass-derived production of the platform chemical triacetic acid lactone by engineered cell factories",

abstract = "As an important platform chemical, triacetic acid lactone (TAL) is considered the “bridge” molecule between biotransformation and chemical catalysis. The conventional production methods relying on plant extraction and chemical conversion restricted its large-scale application due to limited natural resources and serious environmental concerns. The conversion of low-cost biomass-derived carbohydrates into platform molecules by engineered microbes provides a promising alternative to produce a variety of end products with commercial values. In this review, we summarized the research progress of TAL biomanufacturing via biological approach by the metabolically engineered cell factories, including the construction of efficient biosynthetic pathways in different hosts, the development and pretreatment of biomass and industrial waste as feedstocks, and the establishment of the novel biosensor to enhance TAL synthesis. Despite the biosynthesis of TAL successfully achieved by these strategies, there are still great challenges to making the biomanufacturing of TAL economically viable. Some issues in the bio-production of TAL were discussed and potential strategies to improve the techno-economic feasibility were proposed in this review. It was hoped that these views could help to provide more rational and feasible ways for cost-efficient manufacturing of TAL by engineered microbes.",

keywords = "Biosensor, Lignocellulose, Metabolic engineering, Triacetic acid lactone",

author = "Yangming Liu and Yuhan Jin and Peng Xu and Li Deng and Huan Liu and Fang Wang",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier B.V.",

year = "2023",

month = aug,

doi = "10.1016/j.bej.2023.108961",

language = "英语",

volume = "197",

journal = "Biochemical Engineering Journal",

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T1 - Recent advances and perspectives on the biomass-derived production of the platform chemical triacetic acid lactone by engineered cell factories

AU - Liu, Yangming

AU - Jin, Yuhan

AU - Xu, Peng

AU - Deng, Li

AU - Liu, Huan

AU - Wang, Fang

PY - 2023/8

Y1 - 2023/8

N2 - As an important platform chemical, triacetic acid lactone (TAL) is considered the “bridge” molecule between biotransformation and chemical catalysis. The conventional production methods relying on plant extraction and chemical conversion restricted its large-scale application due to limited natural resources and serious environmental concerns. The conversion of low-cost biomass-derived carbohydrates into platform molecules by engineered microbes provides a promising alternative to produce a variety of end products with commercial values. In this review, we summarized the research progress of TAL biomanufacturing via biological approach by the metabolically engineered cell factories, including the construction of efficient biosynthetic pathways in different hosts, the development and pretreatment of biomass and industrial waste as feedstocks, and the establishment of the novel biosensor to enhance TAL synthesis. Despite the biosynthesis of TAL successfully achieved by these strategies, there are still great challenges to making the biomanufacturing of TAL economically viable. Some issues in the bio-production of TAL were discussed and potential strategies to improve the techno-economic feasibility were proposed in this review. It was hoped that these views could help to provide more rational and feasible ways for cost-efficient manufacturing of TAL by engineered microbes.

AB - As an important platform chemical, triacetic acid lactone (TAL) is considered the “bridge” molecule between biotransformation and chemical catalysis. The conventional production methods relying on plant extraction and chemical conversion restricted its large-scale application due to limited natural resources and serious environmental concerns. The conversion of low-cost biomass-derived carbohydrates into platform molecules by engineered microbes provides a promising alternative to produce a variety of end products with commercial values. In this review, we summarized the research progress of TAL biomanufacturing via biological approach by the metabolically engineered cell factories, including the construction of efficient biosynthetic pathways in different hosts, the development and pretreatment of biomass and industrial waste as feedstocks, and the establishment of the novel biosensor to enhance TAL synthesis. Despite the biosynthesis of TAL successfully achieved by these strategies, there are still great challenges to making the biomanufacturing of TAL economically viable. Some issues in the bio-production of TAL were discussed and potential strategies to improve the techno-economic feasibility were proposed in this review. It was hoped that these views could help to provide more rational and feasible ways for cost-efficient manufacturing of TAL by engineered microbes.

KW - Biosensor

KW - Lignocellulose

KW - Metabolic engineering

KW - Triacetic acid lactone

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DO - 10.1016/j.bej.2023.108961

M3 - 文献综述

SN - 1369-703X

VL - 197

JO - Biochemical Engineering Journal

JF - Biochemical Engineering Journal

M1 - 108961

ER -

Recent advances and perspectives on the biomass-derived production of the platform chemical triacetic acid lactone by engineered cell factories

Abstract

Keywords

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