Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery: In vivo

X. Luo, W. Wang, J. R. Dorkin, O. Veiseh, P. H. Chang, I. Abutbul-Ionita, D. Danino, R. Langer, D. G. Anderson*, Y. Dong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

Original languageEnglish
Pages (from-to)38-40
Number of pages3
JournalBiomaterials Science
Volume5
Issue number1
DOIs
StatePublished - Jan 2017
Externally publishedYes

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