Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery: In vivo

X. Luo; W. Wang; J. R. Dorkin; O. Veiseh; P. H. Chang; I. Abutbul-Ionita; D. Danino; R. Langer; D. G. Anderson; Y. Dong

doi:10.1039/c6bm00683c

Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery: In vivo

X. Luo, W. Wang, J. R. Dorkin, O. Veiseh, P. H. Chang, I. Abutbul-Ionita, D. Danino, R. Langer, D. G. Anderson^*, Y. Dong

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

Original language	English
Pages (from-to)	38-40
Number of pages	3
Journal	Biomaterials Science
Volume	5
Issue number	1
DOIs	https://doi.org/10.1039/c6bm00683c
State	Published - Jan 2017
Externally published	Yes

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title = "Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery: In vivo",

abstract = "Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.",

author = "X. Luo and W. Wang and Dorkin, {J. R.} and O. Veiseh and Chang, {P. H.} and I. Abutbul-Ionita and D. Danino and R. Langer and Anderson, {D. G.} and Y. Dong",

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T2 - In vivo

AU - Luo, X.

AU - Wang, W.

AU - Dorkin, J. R.

AU - Veiseh, O.

AU - Chang, P. H.

AU - Abutbul-Ionita, I.

AU - Danino, D.

AU - Langer, R.

AU - Anderson, D. G.

AU - Dong, Y.

PY - 2017/1

Y1 - 2017/1

N2 - Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

AB - Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

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U2 - 10.1039/c6bm00683c

DO - 10.1039/c6bm00683c

M3 - 文章

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SN - 2047-4830

VL - 5

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EP - 40

JO - Biomaterials Science

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ER -

Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery: In vivo

Abstract

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