Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery: In vivo

X. Luo, W. Wang, J. R. Dorkin, O. Veiseh, P. H. Chang, I. Abutbul-Ionita, D. Danino, R. Langer, D. G. Anderson*, Y. Dong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

Original languageEnglish
Pages (from-to)38-40
Number of pages3
JournalBiomaterials Science
Issue number1
StatePublished - Jan 2017
Externally publishedYes


Dive into the research topics of 'Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery: In vivo'. Together they form a unique fingerprint.

Cite this