PEG coated vesicles from mixtures of Pluronic P123 and l-α-phosphatidylcholine: Structure, rheology and curcumin encapsulation

Bijaideep Dutta; K. C. Barick; Gunjan Verma; V. K. Aswal; Inbar Freilich; Dganit Danino; B. G. Singh; K. I. Priyadarsini; P. A. Hassan

doi:10.1039/c7cp05303g

PEG coated vesicles from mixtures of Pluronic P123 and l-α-phosphatidylcholine: Structure, rheology and curcumin encapsulation

Bijaideep Dutta, K. C. Barick, Gunjan Verma, V. K. Aswal, Inbar Freilich, Dganit Danino, B. G. Singh, K. I. Priyadarsini, P. A. Hassan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

PEG coated vesicles are important vehicles for the passive targeting of anticancer drugs. With a view to prepare PEG decorated vesicles using co-assembly of block copolymers and lipids, here we investigated the microstructure of aggregates formed in mixtures comprising lipids (l-α-phosphatidylcholine) and block copolymers (Pluronic P123), in the polymer rich regime. DLS and SANS studies show that the structure of the aggregates can be tuned from micelles to rod-like micelles or vesicles by changing the lipid to polymer composition. Rheological studies on gels formed by mixtures of polymer and lipid suggest incorporation of the lipid into the polymer matrix. The encapsulation efficiencies of polymer incorporated liposomes for curcumin and doxorubicin hydrochloride (DOX) are evaluated at different drug to carrier ratios. The pH dependent sustained release of both the drugs from the PEGylated liposomes suggests their application in the development of cost effective formulations for anticancer drug delivery.

Original language	English
Pages (from-to)	26821-26832
Number of pages	12
Journal	Physical Chemistry Chemical Physics
Volume	19
Issue number	39
DOIs	https://doi.org/10.1039/c7cp05303g
State	Published - 2017
Externally published	Yes

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title = "PEG coated vesicles from mixtures of Pluronic P123 and l-α-phosphatidylcholine: Structure, rheology and curcumin encapsulation",

abstract = "PEG coated vesicles are important vehicles for the passive targeting of anticancer drugs. With a view to prepare PEG decorated vesicles using co-assembly of block copolymers and lipids, here we investigated the microstructure of aggregates formed in mixtures comprising lipids (l-α-phosphatidylcholine) and block copolymers (Pluronic P123), in the polymer rich regime. DLS and SANS studies show that the structure of the aggregates can be tuned from micelles to rod-like micelles or vesicles by changing the lipid to polymer composition. Rheological studies on gels formed by mixtures of polymer and lipid suggest incorporation of the lipid into the polymer matrix. The encapsulation efficiencies of polymer incorporated liposomes for curcumin and doxorubicin hydrochloride (DOX) are evaluated at different drug to carrier ratios. The pH dependent sustained release of both the drugs from the PEGylated liposomes suggests their application in the development of cost effective formulations for anticancer drug delivery.",

author = "Bijaideep Dutta and Barick, {K. C.} and Gunjan Verma and Aswal, {V. K.} and Inbar Freilich and Dganit Danino and Singh, {B. G.} and Priyadarsini, {K. I.} and Hassan, {P. A.}",

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year = "2017",

doi = "10.1039/c7cp05303g",

language = "英语",

volume = "19",

pages = "26821--26832",

journal = "Physical Chemistry Chemical Physics",

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T1 - PEG coated vesicles from mixtures of Pluronic P123 and l-α-phosphatidylcholine

T2 - Structure, rheology and curcumin encapsulation

AU - Dutta, Bijaideep

AU - Barick, K. C.

AU - Verma, Gunjan

AU - Aswal, V. K.

AU - Freilich, Inbar

AU - Danino, Dganit

AU - Singh, B. G.

AU - Priyadarsini, K. I.

AU - Hassan, P. A.

PY - 2017

Y1 - 2017

N2 - PEG coated vesicles are important vehicles for the passive targeting of anticancer drugs. With a view to prepare PEG decorated vesicles using co-assembly of block copolymers and lipids, here we investigated the microstructure of aggregates formed in mixtures comprising lipids (l-α-phosphatidylcholine) and block copolymers (Pluronic P123), in the polymer rich regime. DLS and SANS studies show that the structure of the aggregates can be tuned from micelles to rod-like micelles or vesicles by changing the lipid to polymer composition. Rheological studies on gels formed by mixtures of polymer and lipid suggest incorporation of the lipid into the polymer matrix. The encapsulation efficiencies of polymer incorporated liposomes for curcumin and doxorubicin hydrochloride (DOX) are evaluated at different drug to carrier ratios. The pH dependent sustained release of both the drugs from the PEGylated liposomes suggests their application in the development of cost effective formulations for anticancer drug delivery.

AB - PEG coated vesicles are important vehicles for the passive targeting of anticancer drugs. With a view to prepare PEG decorated vesicles using co-assembly of block copolymers and lipids, here we investigated the microstructure of aggregates formed in mixtures comprising lipids (l-α-phosphatidylcholine) and block copolymers (Pluronic P123), in the polymer rich regime. DLS and SANS studies show that the structure of the aggregates can be tuned from micelles to rod-like micelles or vesicles by changing the lipid to polymer composition. Rheological studies on gels formed by mixtures of polymer and lipid suggest incorporation of the lipid into the polymer matrix. The encapsulation efficiencies of polymer incorporated liposomes for curcumin and doxorubicin hydrochloride (DOX) are evaluated at different drug to carrier ratios. The pH dependent sustained release of both the drugs from the PEGylated liposomes suggests their application in the development of cost effective formulations for anticancer drug delivery.

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DO - 10.1039/c7cp05303g

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AN - SCOPUS:85031320704

SN - 1463-9076

VL - 19

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JO - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

IS - 39

ER -

PEG coated vesicles from mixtures of Pluronic P123 and l-α-phosphatidylcholine: Structure, rheology and curcumin encapsulation

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