One particle, two targets: A combined action of functionalised gold nanoparticles, against Pseudomonas fluorescens biofilms

Olivier Habimana, Michele Zanoni, Stefania Vitale, Tiina O'Neill, Dimitri Scholz, Bin Xu, Eoin Casey*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Attempts to deal with the problem of detrimental biofilms using nanoparticle technologies have generally focussed on exploiting biocidal approaches. However, it is now recognised that biofilm matrix-components may be targets for the disruption or dispersion of biofilms. Here, we show that the functionalization of gold nanoparticles with the enzyme, proteinase-K (PK) led to both biocidal and matrix disruption effects within Pseudomonas fluorescens biofilms and released cells. This study highlights the potential mechanisms underpinning the properties of Proteinase-K functionalized gold nanoparticles. With the emergence of biocide-resistant biofilm-forming organisms, novel nanoparticle strategies may provide the ideal solution for disrupting and inactivating biofilm cells, thereby minimising the use of biocides or antibiotics.

Original languageEnglish
Pages (from-to)419-428
Number of pages10
JournalJournal of Colloid and Interface Science
Volume526
DOIs
StatePublished - 15 Sep 2018
Externally publishedYes

Keywords

  • Biofilm
  • Enzyme
  • Nanoparticle

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