TY - JOUR
T1 - Nanochemoprevention with therapeutic benefits
T2 - An updated review focused on epigallocatechin gallate delivery
AU - Yang, Qiong Qiong
AU - Wei, Xin Lin
AU - Fang, Ya Peng
AU - Gan, Ren You
AU - Wang, Min
AU - Ge, Ying Ying
AU - Zhang, Dan
AU - Cheng, Li Zeng
AU - Corke, Harold
N1 - Publisher Copyright:
© 2019, © 2019 Taylor & Francis Group, LLC.
PY - 2020/4/27
Y1 - 2020/4/27
N2 - Epigallocatechin gallate (EGCG) is a natural phenolic compound found in many plants, especially in green tea, which is a popular and restorative beverage with many claimed health benefits such as antioxidant, anti-cancer, anti-microbial, anti-diabetic, and anti-obesity activities. Despite its great curative potential, the poor bioavailability of EGCG restricts its clinical applcation. However, nanoformulations of EGCG are emerging as new alternatives to traditional formulations. This review focuses on the nanochemopreventive applications of various EGCG nanoparticles such as lipid-based, polymer-based, carbohydrate-based, protein-based, and metal-based nanoparticles. EGCG hybridized with these nanocarriers is capable of achieving advanced functions such as targeted release, active targeting, and enhanced penetration, ultimately increasing the bioavailability of EGCG. In addition, this review also summarizes the challenges for the use of EGCG in therapeutic applications, and suggests future directions for progress.
AB - Epigallocatechin gallate (EGCG) is a natural phenolic compound found in many plants, especially in green tea, which is a popular and restorative beverage with many claimed health benefits such as antioxidant, anti-cancer, anti-microbial, anti-diabetic, and anti-obesity activities. Despite its great curative potential, the poor bioavailability of EGCG restricts its clinical applcation. However, nanoformulations of EGCG are emerging as new alternatives to traditional formulations. This review focuses on the nanochemopreventive applications of various EGCG nanoparticles such as lipid-based, polymer-based, carbohydrate-based, protein-based, and metal-based nanoparticles. EGCG hybridized with these nanocarriers is capable of achieving advanced functions such as targeted release, active targeting, and enhanced penetration, ultimately increasing the bioavailability of EGCG. In addition, this review also summarizes the challenges for the use of EGCG in therapeutic applications, and suggests future directions for progress.
KW - EGCG
KW - Polyphenol
KW - drug delivery
KW - nanoparticle
KW - nanotechnology
UR - http://www.scopus.com/inward/record.url?scp=85082791967&partnerID=8YFLogxK
U2 - 10.1080/10408398.2019.1565490
DO - 10.1080/10408398.2019.1565490
M3 - 文献综述
C2 - 30799648
AN - SCOPUS:85082791967
SN - 1040-8398
VL - 60
SP - 1243
EP - 1264
JO - Critical Reviews in Food Science and Nutrition
JF - Critical Reviews in Food Science and Nutrition
IS - 8
ER -
