Modelling of E. Coli fermentations: Comparison of multicompartment and variable structure models

B. Tartakovsky, M. Sheintuch, J. M. Hilmer, T. Scheper

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Two novel approaches for modelling processes that can be described by a sequence of phases (metabolic states) are suggested and applied to Escherichia Coli fermentations. The first approach uses a multi-compartment model framework, coupled with knowledge-based logic. In X the second approach the multi-compartment model is reduced into the Variable Structure Model consisting of a battery of alternative submodels, each of which qualitatively represents one of the process steps. Furthermore, simulated intracellular process variables are compared with the output of a multi-wavelength fluorosensor and excitation-emission pairs that predict best these variables are identified.

Original languageEnglish
Pages (from-to)323-329
Number of pages7
JournalBioprocess Engineering
Volume16
Issue number6
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Dive into the research topics of 'Modelling of E. Coli fermentations: Comparison of multicompartment and variable structure models'. Together they form a unique fingerprint.

Cite this