Mild catalytic deoxygenation of amides promoted by thorium metallocene

Sayantani Saha, Moris S. Eisen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The organoactinide-catalyzed (Cp*2ThMe2) hydroborated reduction of a wide range of tertiary, secondary, and primary amides to the corresponding amines/amine-borane adductsviadeoxygenation of the amides is reported herein. The catalytic reactions proceed under mild conditions with low catalyst loading and pinacolborane (HBpin) concentration in a selective fashion. Cp*2ThMe2is capable of efficiently catalysing the gram-scale reaction without a drop in efficiency. The amine-borane adducts are successfully converted into free amine products in high conversions, which increases the usefulness of this catalytic system. A plausible mechanism is proposed based on detailed kinetics, stoichiometric, and deuterium labeling studies.

Original languageEnglish
Pages (from-to)12835-12841
Number of pages7
JournalDalton Transactions
Issue number36
StatePublished - 28 Sep 2020
Externally publishedYes


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