Microfluidic Applications in Drug Development: Fabrication of Drug Carriers and Drug Toxicity Screening

Pei Zhao; Jianchun Wang; Chengmin Chen; Jianmei Wang; Guangxia Liu; Krishnaswamy Nandakumar; Yan Li; Liqiu Wang

doi:10.3390/mi13020200

Microfluidic Applications in Drug Development: Fabrication of Drug Carriers and Drug Toxicity Screening

Pei Zhao, Jianchun Wang, Chengmin Chen, Jianmei Wang, Guangxia Liu, Krishnaswamy Nandakumar, Yan Li^*, Liqiu Wang^*

^*Corresponding author for this work

Chemical Engineering

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Microfluidic technology has been highly useful in nanovolume sample preparation, sepa-ration, synthesis, purification, detection and assay, which are advantageous in drug development. This review highlights the recent developments and trends in microfluidic applications in two areas of drug development. First, we focus on how microfluidics has been developed as a facile tool for the fabrication of drug carriers including microparticles and nanoparticles. Second, we discuss how microfluidic chips could be used as an independent platform or integrated with other technologies in drug toxicity screening. Challenges and future perspectives of microfluidic applications in drug development have also been provided considering the present technological limitations.

Original language	English
Article number	200
Journal	Micromachines
Volume	13
Issue number	2
DOIs	https://doi.org/10.3390/mi13020200
State	Published - Feb 2022

Keywords

Drug carrier
Drug development
Drug toxicity screening
Micro/nanoparticles
Microfluidic technology
Organs-on-chips

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10.3390/mi13020200

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title = "Microfluidic Applications in Drug Development: Fabrication of Drug Carriers and Drug Toxicity Screening",

abstract = "Microfluidic technology has been highly useful in nanovolume sample preparation, sepa-ration, synthesis, purification, detection and assay, which are advantageous in drug development. This review highlights the recent developments and trends in microfluidic applications in two areas of drug development. First, we focus on how microfluidics has been developed as a facile tool for the fabrication of drug carriers including microparticles and nanoparticles. Second, we discuss how microfluidic chips could be used as an independent platform or integrated with other technologies in drug toxicity screening. Challenges and future perspectives of microfluidic applications in drug development have also been provided considering the present technological limitations.",

keywords = "Drug carrier, Drug development, Drug toxicity screening, Micro/nanoparticles, Microfluidic technology, Organs-on-chips",

author = "Pei Zhao and Jianchun Wang and Chengmin Chen and Jianmei Wang and Guangxia Liu and Krishnaswamy Nandakumar and Yan Li and Liqiu Wang",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = feb,

doi = "10.3390/mi13020200",

language = "英语",

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T1 - Microfluidic Applications in Drug Development

T2 - Fabrication of Drug Carriers and Drug Toxicity Screening

AU - Zhao, Pei

AU - Wang, Jianchun

AU - Chen, Chengmin

AU - Wang, Jianmei

AU - Liu, Guangxia

AU - Nandakumar, Krishnaswamy

AU - Li, Yan

AU - Wang, Liqiu

PY - 2022/2

Y1 - 2022/2

N2 - Microfluidic technology has been highly useful in nanovolume sample preparation, sepa-ration, synthesis, purification, detection and assay, which are advantageous in drug development. This review highlights the recent developments and trends in microfluidic applications in two areas of drug development. First, we focus on how microfluidics has been developed as a facile tool for the fabrication of drug carriers including microparticles and nanoparticles. Second, we discuss how microfluidic chips could be used as an independent platform or integrated with other technologies in drug toxicity screening. Challenges and future perspectives of microfluidic applications in drug development have also been provided considering the present technological limitations.

AB - Microfluidic technology has been highly useful in nanovolume sample preparation, sepa-ration, synthesis, purification, detection and assay, which are advantageous in drug development. This review highlights the recent developments and trends in microfluidic applications in two areas of drug development. First, we focus on how microfluidics has been developed as a facile tool for the fabrication of drug carriers including microparticles and nanoparticles. Second, we discuss how microfluidic chips could be used as an independent platform or integrated with other technologies in drug toxicity screening. Challenges and future perspectives of microfluidic applications in drug development have also been provided considering the present technological limitations.

KW - Drug carrier

KW - Drug development

KW - Drug toxicity screening

KW - Micro/nanoparticles

KW - Microfluidic technology

KW - Organs-on-chips

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U2 - 10.3390/mi13020200

DO - 10.3390/mi13020200

M3 - 文献综述

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SN - 2072-666X

VL - 13

JO - Micromachines

JF - Micromachines

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ER -

Microfluidic Applications in Drug Development: Fabrication of Drug Carriers and Drug Toxicity Screening

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Keywords

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