Direct CH amidation of arylphosphoryl compounds has been developed by using an IrIIIcatalyst system under mild conditions. A wide range of substrates could be employed with high functional-group tolerance. This procedure was successfully applied for the first time to the asymmetric reaction giving rise to a P-chirogenic center with a high diastereomeric ratio of up to 19:1 (90 % de).
|Number of pages||5|
|Journal||Chemistry - A European Journal|
|State||Published - 22 Sep 2014|
- CH functionalization
- asymmetric induction
- iridium catalysis
- phosphine oxides