Engineering applications of bioluminescence:. Modelling of mass transfer in a hollow fiber and in a chemostat

M. Sheintuch; O. Vashitz; A. Wolffberg

doi:10.1016/0009-2509(92)87102-V

Engineering applications of bioluminescence:. Modelling of mass transfer in a hollow fiber and in a chemostat

M. Sheintuch^*, O. Vashitz, A. Wolffberg

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A probing method based on bioluminescence was developed and applied for studies of mass transfer, kinetics and feed optimization. We present here two applications that require modelling of the process for purposes of model discrimination and parameter estimation. Oxygen diffusivity in the cell-layer of a hollow-fiber reactor is estimated matching the luminescence measurements along such a reactor with the heterogeneous model of a plug-flow reactor. The transfer mechanism of substrates from the liquid phase to the cell in a chemostat is determined by following luminescence oscillations forced by periodic pumping of the substrate. The mechanism is elucidated fot the disparity between the period of the oscillations and the reactor residence time. Mass transfer coefficients are determined for the observed amplitude.

Original language	English
Pages (from-to)	2615-2620
Number of pages	6
Journal	Chemical Engineering Science
Volume	47
Issue number	9-11
DOIs	https://doi.org/10.1016/0009-2509(92)87102-V
State	Published - 8 Jun 1992
Externally published	Yes

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title = "Engineering applications of bioluminescence:. Modelling of mass transfer in a hollow fiber and in a chemostat",

abstract = "A probing method based on bioluminescence was developed and applied for studies of mass transfer, kinetics and feed optimization. We present here two applications that require modelling of the process for purposes of model discrimination and parameter estimation. Oxygen diffusivity in the cell-layer of a hollow-fiber reactor is estimated matching the luminescence measurements along such a reactor with the heterogeneous model of a plug-flow reactor. The transfer mechanism of substrates from the liquid phase to the cell in a chemostat is determined by following luminescence oscillations forced by periodic pumping of the substrate. The mechanism is elucidated fot the disparity between the period of the oscillations and the reactor residence time. Mass transfer coefficients are determined for the observed amplitude.",

author = "M. Sheintuch and O. Vashitz and A. Wolffberg",

year = "1992",

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doi = "10.1016/0009-2509(92)87102-V",

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T1 - Engineering applications of bioluminescence:. Modelling of mass transfer in a hollow fiber and in a chemostat

AU - Sheintuch, M.

AU - Vashitz, O.

AU - Wolffberg, A.

PY - 1992/6/8

Y1 - 1992/6/8

N2 - A probing method based on bioluminescence was developed and applied for studies of mass transfer, kinetics and feed optimization. We present here two applications that require modelling of the process for purposes of model discrimination and parameter estimation. Oxygen diffusivity in the cell-layer of a hollow-fiber reactor is estimated matching the luminescence measurements along such a reactor with the heterogeneous model of a plug-flow reactor. The transfer mechanism of substrates from the liquid phase to the cell in a chemostat is determined by following luminescence oscillations forced by periodic pumping of the substrate. The mechanism is elucidated fot the disparity between the period of the oscillations and the reactor residence time. Mass transfer coefficients are determined for the observed amplitude.

AB - A probing method based on bioluminescence was developed and applied for studies of mass transfer, kinetics and feed optimization. We present here two applications that require modelling of the process for purposes of model discrimination and parameter estimation. Oxygen diffusivity in the cell-layer of a hollow-fiber reactor is estimated matching the luminescence measurements along such a reactor with the heterogeneous model of a plug-flow reactor. The transfer mechanism of substrates from the liquid phase to the cell in a chemostat is determined by following luminescence oscillations forced by periodic pumping of the substrate. The mechanism is elucidated fot the disparity between the period of the oscillations and the reactor residence time. Mass transfer coefficients are determined for the observed amplitude.

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JO - Chemical Engineering Science

JF - Chemical Engineering Science

IS - 9-11

ER -

Engineering applications of bioluminescence:. Modelling of mass transfer in a hollow fiber and in a chemostat

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