Effects and mechanisms of tea and its bioactive compounds for the prevention and treatment of cardiovascular diseases: An updated review

TY - JOUR

T1 - Effects and mechanisms of tea and its bioactive compounds for the prevention and treatment of cardiovascular diseases

T2 - An updated review

AU - Cao, Shi Yu

AU - Zhao, Cai Ning

AU - Gan, Ren You

AU - Xu, Xiao Yu

AU - Wei, Xin Lin

AU - Corke, Harold

AU - Atanasov, Atanas G.

AU - Li, Hua Bin

N1 - Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. All rights reserved.

PY - 2019/6

Y1 - 2019/6

N2 - Cardiovascular diseases (CVDs) are critical global public health issues with high morbidity and mortality. Epidemiological studies have revealed that regular tea drinking is inversely associated with the risk of CVDs. Additionally, substantial in vitro and in vivo experimental studies have shown that tea and its bioactive compounds are effective in protecting against CVDs. The relevant mechanisms include reducing blood lipid, alleviating ischemia/reperfusion injury, inhibiting oxidative stress, enhancing endothelial function, attenuating inflammation, and protecting cardiomyocyte function. Moreover, some clinical trials also proved the protective role of tea against CVDs. In order to provide a better understanding of the relationship between tea and CVDs, this review summarizes the effects of tea and its bioactive compounds against CVDs and discusses potential mechanisms of action based on evidence from epidemiological, experimental, and clinical studies.

AB - Cardiovascular diseases (CVDs) are critical global public health issues with high morbidity and mortality. Epidemiological studies have revealed that regular tea drinking is inversely associated with the risk of CVDs. Additionally, substantial in vitro and in vivo experimental studies have shown that tea and its bioactive compounds are effective in protecting against CVDs. The relevant mechanisms include reducing blood lipid, alleviating ischemia/reperfusion injury, inhibiting oxidative stress, enhancing endothelial function, attenuating inflammation, and protecting cardiomyocyte function. Moreover, some clinical trials also proved the protective role of tea against CVDs. In order to provide a better understanding of the relationship between tea and CVDs, this review summarizes the effects of tea and its bioactive compounds against CVDs and discusses potential mechanisms of action based on evidence from epidemiological, experimental, and clinical studies.

KW - Bioactive compounds

KW - Cardiovascular diseases

KW - EGCG

KW - Mechanisms

KW - Polyphenols

KW - Tea

UR - http://www.scopus.com/inward/record.url?scp=85070711610&partnerID=8YFLogxK

U2 - 10.3390/antiox8060166

DO - 10.3390/antiox8060166

M3 - 文献综述

AN - SCOPUS:85070711610

SN - 2076-3921

VL - 8

JO - Antioxidants

JF - Antioxidants

IS - 6

M1 - 166

ER -