TY - JOUR
T1 - Edwardsiella piscicida
T2 - A versatile emerging pathogen of fish
AU - Leung, Ka Yin
AU - Wang, Qiyao
AU - Yang, Zhiyun
AU - Siame, Bupe A.
N1 - Publisher Copyright:
© 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Edwardsiella piscicida is an Enterobacteriaceae that is abundant in water and causes food and waterborne infections in fish, animals, and humans. The bacterium causes Edwardsiellosis in farmed fish and can lead to severe economic losses in aquaculture worldwide. E. piscicida is an intracellular pathogen that can also cause systemic infection. Type III and type VI secretion systems are the bacterium’s most lethal weapons against host defenses. It also possesses multi-antibiotic resistant genes and is selected and enriched in the environment due to the overuse of antibiotics. Therefore, the bacterium has great potential to contribute to the evolution of the resistome. All these properties have made this bacterium a perfect model to study bacteria virulence mechanisms and the spread of antimicrobial genes in the environment. We summarize recent advance in E. piscicida biology and provide insights into future research in virulence mechanisms, vaccine development and novel therapeutics.
AB - Edwardsiella piscicida is an Enterobacteriaceae that is abundant in water and causes food and waterborne infections in fish, animals, and humans. The bacterium causes Edwardsiellosis in farmed fish and can lead to severe economic losses in aquaculture worldwide. E. piscicida is an intracellular pathogen that can also cause systemic infection. Type III and type VI secretion systems are the bacterium’s most lethal weapons against host defenses. It also possesses multi-antibiotic resistant genes and is selected and enriched in the environment due to the overuse of antibiotics. Therefore, the bacterium has great potential to contribute to the evolution of the resistome. All these properties have made this bacterium a perfect model to study bacteria virulence mechanisms and the spread of antimicrobial genes in the environment. We summarize recent advance in E. piscicida biology and provide insights into future research in virulence mechanisms, vaccine development and novel therapeutics.
KW - Edwardsiella piscicida
KW - T3SS/T6SS and effectors
KW - intracellular and systemic infection
KW - resistome
KW - virulence mechanisms
UR - http://www.scopus.com/inward/record.url?scp=85067374715&partnerID=8YFLogxK
U2 - 10.1080/21505594.2019.1621648
DO - 10.1080/21505594.2019.1621648
M3 - 文献综述
C2 - 31122125
AN - SCOPUS:85067374715
SN - 2150-5594
VL - 10
SP - 555
EP - 567
JO - Virulence
JF - Virulence
IS - 1
ER -