Detection of mcr-1 Gene among Escherichia coli Isolates from Farmed Fish and Characterization of mcr-1-Bearing IncP Plasmids

Luchao Lv, Yuping Cao, Peixin Yu, Raorao Huang, Jing Wang, Qiaoling Wen, Chanping Zhi, Qianhui Zhang, Jian Hua Liu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The presence of the mcr-1 gene in Escherichia coli isolated from retail freshwater fish was investigated. Seven (3.65%) clonally unrelated original E. coli isolates from grass carp were positive for mcr-1. The mcr-1 genes were encoded by either chromosomes (n 2) or conjugative plasmids (2 IncI2, 2 IncP, and 1 IncX4). The IncP plasmids were similar to other mcr-1-harboring IncP plasmids from China, though the insertion sites varied. Our report warrants further surveillance of resistance genes in aquaculture.

Original languageEnglish
Article numbere02378-17
JournalAntimicrobial Agents and Chemotherapy
Volume62
Issue number3
DOIs
StatePublished - Mar 2018
Externally publishedYes

Keywords

  • Colistin resistance
  • Enterobacteriaceae
  • Escherichia coli
  • Fish
  • IncP
  • Mcr-1
  • Plasmid mediated

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