During trips and outdoor adventures, there are a lot of electric equipment and thus power supply for those devices is critical. At the same time, the burden on shoulders from heavy baggage is substantial. This paper presents a one-way energy harvesting backpack with ball-screw mechanism to generate electricity with high efficiency and reliability, while relieves the burden on shoulders. The one-way energy harvesting method only harvests negative work from human body and potentially reduce metabolic cost while carrying backpack. Simulations show that 4.5W of electrical energy can be obtained from human walking. Bench test results indicate this system can obtain an average power of 7.3 W with excitation of 2Hz and 25mm direct drive. Treadmill test to verify the performance of burden relieve on shoulders indicates this one-way design combing with elastic support strap can reduce the force on shoulders, which reduce fatigue in human.