Comparative proteomic analysis of extracellular proteins of Edwardsiella tarda

Y. P. Tan, Q. Lin, X. H. Wang, S. Joshi, C. L. Hew, K. Y. Leung*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


A comparison of extracellular proteins of virulent and avirulent Edwardsiella tarda strains revealed several major, virulent-strain-specific proteins. Proteomic analysis identified two of the proteins in the virulent strain PPD130/91 as flagellin and SseB, which are virulence factors in bacterial pathogens. PCR amplification and DNA sequencing confirmed the presence of the genes that encode these proteins. Our results clearly demonstrated the potency of the proteomic approach in identifying virulence factors.

Original languageEnglish
Pages (from-to)6475-6480
Number of pages6
JournalInfection and Immunity
Issue number11
StatePublished - Nov 2002
Externally publishedYes


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