TY - JOUR
T1 - Antimicrobial and anticancer applications and related mechanisms of curcumin-mediated photodynamic treatments
AU - Yang, Qiong Qiong
AU - Farha, Arakkaveettil Kabeer
AU - Kim, Gowoon
AU - Gul, Khalid
AU - Gan, Ren You
AU - Corke, Harold
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/3
Y1 - 2020/3
N2 - Background: Curcumin has gained increasing attention in recent years due to its biological properties and photosensitivity. Curcumin-mediated photodynamic therapy has been used in antibacterial and anticancer applications. Considering the importance and rapid advances in curcumin-mediated photodynamic treatments and its related beneficial functions, a comprehensive and up-to-date review is timely to summarize the state-of-art in this area and to suggest directions for future progress. Scope and approach: In this review, photodynamic therapies (PDT) with curcumin as photosensitizers are discussed, with particular emphasis on their application in anticancer and antibacterial therapies. Through photodynamic activation, enhanced therapeutic effect of curcumin is readily exhibited towards cancer and bacterial treatments. In addition, modification of curcumin with metal complexes and encapsulation of curcumin in nano delivery systems to enhance the PDT effect are discussed. Special emphasis is given to the mechanisms of curcumin-related PDT and to suggest future directions for progress. Key findings and conclusions: The key finding of this review is that curcumin in combination with PDT can enhance the therapeutic effects of native curcumin against microbiota and cancer cell lines. However, there is still a lack of curcumin-PDT in vivo studies, and targeted delivery of curcumin has not yet been studied sufficiently, despite clear evidence for its potential. For future studies, more in vivo studies are needed, and the nano-delivery systems for curcumin can be modified with aptamers to realize targeted delivery and to enhance the PDT effect.
AB - Background: Curcumin has gained increasing attention in recent years due to its biological properties and photosensitivity. Curcumin-mediated photodynamic therapy has been used in antibacterial and anticancer applications. Considering the importance and rapid advances in curcumin-mediated photodynamic treatments and its related beneficial functions, a comprehensive and up-to-date review is timely to summarize the state-of-art in this area and to suggest directions for future progress. Scope and approach: In this review, photodynamic therapies (PDT) with curcumin as photosensitizers are discussed, with particular emphasis on their application in anticancer and antibacterial therapies. Through photodynamic activation, enhanced therapeutic effect of curcumin is readily exhibited towards cancer and bacterial treatments. In addition, modification of curcumin with metal complexes and encapsulation of curcumin in nano delivery systems to enhance the PDT effect are discussed. Special emphasis is given to the mechanisms of curcumin-related PDT and to suggest future directions for progress. Key findings and conclusions: The key finding of this review is that curcumin in combination with PDT can enhance the therapeutic effects of native curcumin against microbiota and cancer cell lines. However, there is still a lack of curcumin-PDT in vivo studies, and targeted delivery of curcumin has not yet been studied sufficiently, despite clear evidence for its potential. For future studies, more in vivo studies are needed, and the nano-delivery systems for curcumin can be modified with aptamers to realize targeted delivery and to enhance the PDT effect.
KW - Biofilm destruction
KW - Nanoparticles
KW - Natural drug
KW - Photodynamic therapy
KW - Photosensitizer
KW - Reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=85078221628&partnerID=8YFLogxK
U2 - 10.1016/j.tifs.2020.01.023
DO - 10.1016/j.tifs.2020.01.023
M3 - 文献综述
AN - SCOPUS:85078221628
SN - 0924-2244
VL - 97
SP - 341
EP - 354
JO - Trends in Food Science and Technology
JF - Trends in Food Science and Technology
ER -
