An artificial sodium-selective subnanochannel

Jun Lu; Gengping Jiang; Huacheng Zhang; Binbin Qian; Haijin Zhu; Qinfen Gu; Yuan Yan; Jefferson Zhe Liu; Benny D. Freeman; Lei Jiang; Huanting Wang

doi:10.1126/sciadv.abq1369

An artificial sodium-selective subnanochannel

Jun Lu, Gengping Jiang, Huacheng Zhang^*, Binbin Qian, Haijin Zhu, Qinfen Gu, Yuan Yan, Jefferson Zhe Liu^*, Benny D. Freeman, Lei Jiang, Huanting Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Single-ion selectivity with high precision has long been pursued for fundamental bioinspired engineering and applications such as in ion separation and energy conversion. However, it remains a challenge to develop artificial ion channels to achieve single-ion selectivity comparable to their biological analogs, especially for high Na⁺/K⁺ selectivity. Here, we report an artificial sodium channel by subnanoconfinement of 4′-aminobenzo-15-crown-5 ethers (15C5s) into ~6-Å-sized metal-organic framework subnanochannel (MOFSNC). The resulting 15C5-MOFSNC shows an unprecedented Na⁺/K⁺ selectivity of tens to 10² and Na⁺/Li⁺ selectivity of 10³ under multicomponent permeation conditions, comparable to biological sodium channels. A co–ion-responsive single-file transport mechanism in 15C-MOFSNC is proposed for the preferential transport of Na⁺ over K⁺ due to the synergetic effects of size exclusion, charge selectivity, local hydrophobicity, and preferential binding with functional groups. This study provides an alternative strategy for developing potential single-ion selective channels and membranes for many applications.

Original language	English
Article number	eabq1369
Journal	Science advances
Volume	9
Issue number	4
DOIs	https://doi.org/10.1126/sciadv.abq1369
State	Published - Jan 2023
Externally published	Yes

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title = "An artificial sodium-selective subnanochannel",

abstract = "Single-ion selectivity with high precision has long been pursued for fundamental bioinspired engineering and applications such as in ion separation and energy conversion. However, it remains a challenge to develop artificial ion channels to achieve single-ion selectivity comparable to their biological analogs, especially for high Na+/K+ selectivity. Here, we report an artificial sodium channel by subnanoconfinement of 4′-aminobenzo-15-crown-5 ethers (15C5s) into ~6-{\AA}-sized metal-organic framework subnanochannel (MOFSNC). The resulting 15C5-MOFSNC shows an unprecedented Na+/K+ selectivity of tens to 102 and Na+/Li+ selectivity of 103 under multicomponent permeation conditions, comparable to biological sodium channels. A co–ion-responsive single-file transport mechanism in 15C-MOFSNC is proposed for the preferential transport of Na+ over K+ due to the synergetic effects of size exclusion, charge selectivity, local hydrophobicity, and preferential binding with functional groups. This study provides an alternative strategy for developing potential single-ion selective channels and membranes for many applications.",

author = "Jun Lu and Gengping Jiang and Huacheng Zhang and Binbin Qian and Haijin Zhu and Qinfen Gu and Yuan Yan and Liu, {Jefferson Zhe} and Freeman, {Benny D.} and Lei Jiang and Huanting Wang",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 The Authors, some rights reserved.",

year = "2023",

month = jan,

doi = "10.1126/sciadv.abq1369",

language = "英语",

volume = "9",

journal = "Science advances",

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T1 - An artificial sodium-selective subnanochannel

AU - Lu, Jun

AU - Jiang, Gengping

AU - Zhang, Huacheng

AU - Qian, Binbin

AU - Zhu, Haijin

AU - Gu, Qinfen

AU - Yan, Yuan

AU - Liu, Jefferson Zhe

AU - Freeman, Benny D.

AU - Jiang, Lei

AU - Wang, Huanting

PY - 2023/1

Y1 - 2023/1

N2 - Single-ion selectivity with high precision has long been pursued for fundamental bioinspired engineering and applications such as in ion separation and energy conversion. However, it remains a challenge to develop artificial ion channels to achieve single-ion selectivity comparable to their biological analogs, especially for high Na+/K+ selectivity. Here, we report an artificial sodium channel by subnanoconfinement of 4′-aminobenzo-15-crown-5 ethers (15C5s) into ~6-Å-sized metal-organic framework subnanochannel (MOFSNC). The resulting 15C5-MOFSNC shows an unprecedented Na+/K+ selectivity of tens to 102 and Na+/Li+ selectivity of 103 under multicomponent permeation conditions, comparable to biological sodium channels. A co–ion-responsive single-file transport mechanism in 15C-MOFSNC is proposed for the preferential transport of Na+ over K+ due to the synergetic effects of size exclusion, charge selectivity, local hydrophobicity, and preferential binding with functional groups. This study provides an alternative strategy for developing potential single-ion selective channels and membranes for many applications.

AB - Single-ion selectivity with high precision has long been pursued for fundamental bioinspired engineering and applications such as in ion separation and energy conversion. However, it remains a challenge to develop artificial ion channels to achieve single-ion selectivity comparable to their biological analogs, especially for high Na+/K+ selectivity. Here, we report an artificial sodium channel by subnanoconfinement of 4′-aminobenzo-15-crown-5 ethers (15C5s) into ~6-Å-sized metal-organic framework subnanochannel (MOFSNC). The resulting 15C5-MOFSNC shows an unprecedented Na+/K+ selectivity of tens to 102 and Na+/Li+ selectivity of 103 under multicomponent permeation conditions, comparable to biological sodium channels. A co–ion-responsive single-file transport mechanism in 15C-MOFSNC is proposed for the preferential transport of Na+ over K+ due to the synergetic effects of size exclusion, charge selectivity, local hydrophobicity, and preferential binding with functional groups. This study provides an alternative strategy for developing potential single-ion selective channels and membranes for many applications.

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SN - 2375-2548

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JO - Science advances

JF - Science advances

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An artificial sodium-selective subnanochannel

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