Versatile preparation of spherically and mechanically controllable liquid-core-shell alginate-based bead through interfacial gelation

Hongxiang Liu; Fei Liu; Yun Ma; H. Douglas Goff; Fang Zhong

doi:10.1016/j.carbpol.2020.115980

Versatile preparation of spherically and mechanically controllable liquid-core-shell alginate-based bead through interfacial gelation

Hongxiang Liu, Fei Liu^*, Yun Ma, H. Douglas Goff, Fang Zhong

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Developing alginate-based beads with liquid-core-shell structure is highly appealing for industrial applications as a promising delivery matrix material. Herein, based on the reaction-diffusion mechanism, a facile method that includes dissolving natural polymer in calcium ion core solution followed by dripping it to alginate shell bath is proposed through interfacial gelation. By facilely tuning the viscosity and surface tension, the boundary condition for forming spherical beads with applicable mechanical properties was obtained. The universal viscosity-boundary relationship was independent of the type or charge condition of polymers in liquid-core. However, chitosan in the core solution significantly affected mechanical properties due to polyelectrolyte interaction with alginate, based on FTIR and SEM analyses. Moreover, a larger spherical zone was obtained by adding a surfactant into the shell bath. By varying calcium ion concentration and reaction time, beads of superior mechanical properties were obtained with an increase in shell membrane compactness.

Original language	English
Article number	115980
Journal	Carbohydrate Polymers
Volume	236
DOIs	https://doi.org/10.1016/j.carbpol.2020.115980
State	Published - 15 May 2020
Externally published	Yes

Keywords

Alginate
Calcium chloride (PubChem CID: 5284359)
Interfacial gelation
Liquid-core-shell bead
Mechanical property
Sodium alginate (PubChem CID: 133126842)
Sphericity

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10.1016/j.carbpol.2020.115980

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@article{e24bed6d8eb74a5da0c90adb10ecddcb,

title = "Versatile preparation of spherically and mechanically controllable liquid-core-shell alginate-based bead through interfacial gelation",

abstract = "Developing alginate-based beads with liquid-core-shell structure is highly appealing for industrial applications as a promising delivery matrix material. Herein, based on the reaction-diffusion mechanism, a facile method that includes dissolving natural polymer in calcium ion core solution followed by dripping it to alginate shell bath is proposed through interfacial gelation. By facilely tuning the viscosity and surface tension, the boundary condition for forming spherical beads with applicable mechanical properties was obtained. The universal viscosity-boundary relationship was independent of the type or charge condition of polymers in liquid-core. However, chitosan in the core solution significantly affected mechanical properties due to polyelectrolyte interaction with alginate, based on FTIR and SEM analyses. Moreover, a larger spherical zone was obtained by adding a surfactant into the shell bath. By varying calcium ion concentration and reaction time, beads of superior mechanical properties were obtained with an increase in shell membrane compactness.",

keywords = "Alginate, Calcium chloride (PubChem CID: 5284359), Interfacial gelation, Liquid-core-shell bead, Mechanical property, Sodium alginate (PubChem CID: 133126842), Sphericity",

author = "Hongxiang Liu and Fei Liu and Yun Ma and Goff, {H. Douglas} and Fang Zhong",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = may,

day = "15",

doi = "10.1016/j.carbpol.2020.115980",

language = "英语",

volume = "236",

journal = "Carbohydrate Polymers",

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T1 - Versatile preparation of spherically and mechanically controllable liquid-core-shell alginate-based bead through interfacial gelation

AU - Liu, Hongxiang

AU - Liu, Fei

AU - Ma, Yun

AU - Goff, H. Douglas

AU - Zhong, Fang

PY - 2020/5/15

Y1 - 2020/5/15

N2 - Developing alginate-based beads with liquid-core-shell structure is highly appealing for industrial applications as a promising delivery matrix material. Herein, based on the reaction-diffusion mechanism, a facile method that includes dissolving natural polymer in calcium ion core solution followed by dripping it to alginate shell bath is proposed through interfacial gelation. By facilely tuning the viscosity and surface tension, the boundary condition for forming spherical beads with applicable mechanical properties was obtained. The universal viscosity-boundary relationship was independent of the type or charge condition of polymers in liquid-core. However, chitosan in the core solution significantly affected mechanical properties due to polyelectrolyte interaction with alginate, based on FTIR and SEM analyses. Moreover, a larger spherical zone was obtained by adding a surfactant into the shell bath. By varying calcium ion concentration and reaction time, beads of superior mechanical properties were obtained with an increase in shell membrane compactness.

AB - Developing alginate-based beads with liquid-core-shell structure is highly appealing for industrial applications as a promising delivery matrix material. Herein, based on the reaction-diffusion mechanism, a facile method that includes dissolving natural polymer in calcium ion core solution followed by dripping it to alginate shell bath is proposed through interfacial gelation. By facilely tuning the viscosity and surface tension, the boundary condition for forming spherical beads with applicable mechanical properties was obtained. The universal viscosity-boundary relationship was independent of the type or charge condition of polymers in liquid-core. However, chitosan in the core solution significantly affected mechanical properties due to polyelectrolyte interaction with alginate, based on FTIR and SEM analyses. Moreover, a larger spherical zone was obtained by adding a surfactant into the shell bath. By varying calcium ion concentration and reaction time, beads of superior mechanical properties were obtained with an increase in shell membrane compactness.

KW - Alginate

KW - Calcium chloride (PubChem CID: 5284359)

KW - Interfacial gelation

KW - Liquid-core-shell bead

KW - Mechanical property

KW - Sodium alginate (PubChem CID: 133126842)

KW - Sphericity

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U2 - 10.1016/j.carbpol.2020.115980

DO - 10.1016/j.carbpol.2020.115980

M3 - 文章

C2 - 32172829

AN - SCOPUS:85079677568

SN - 0144-8617

VL - 236

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

M1 - 115980

ER -

Versatile preparation of spherically and mechanically controllable liquid-core-shell alginate-based bead through interfacial gelation

Abstract

Keywords

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