TY - JOUR
T1 - Use of carbon supports with copper ion as a highly sensitive non-enzymatic glucose sensor
AU - Zheng, Weiran
AU - Li, Yong
AU - Hu, Liangsheng
AU - Lee, Lawrence Yoon Suk
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Nearly all current non-enzymatic electrochemical glucose sensors involve carefully designed metal/metal oxide nanomaterials and the complications of preparing electrocatalyst increase the fabrication cost and reduce the reproducibility of a sensor. Thus, a simple yet reliable and cost-effective glucose sensing system is much desired. Inspired by the glucose oxidation mechanism of copper-based nanomaterials, we developed a series of highly sensitive electrochemical glucose sensors using micromol level Cu2+ ions as an electrocatalyst. High sensitivities are achieved on various carbon-based electrodes (GCE: 614 mA M−1 cm−2; activated carbon: 1627 mA M−1 cm−2; carbon paper: 2149 mA M−1 cm−2; graphite powder: 1695 mA M−1 cm−2, and functionalized multi-walled carbon nanotube: 1842 mA M−1 cm−2). With short response time (<2 s), large linear range (0.02 μM–2.5 mM and 2.5–8.0 mM), high stability, and excellent tolerance to interference, Cu ion-based sensor was also validated for testing glucose level in real blood samples. Further studies show that carbon support (e.g., MWCNT-COOH) can be doped with nanomolar level Cu2+ to produce a practical solid electrode with an ultra-high sensitivity of 1732 mA M−1 cm−2, retaining the advantage of atomic efficiency. This work provides a new route to the rational design of simple, cheap, and highly effective electrochemical glucose sensors.
AB - Nearly all current non-enzymatic electrochemical glucose sensors involve carefully designed metal/metal oxide nanomaterials and the complications of preparing electrocatalyst increase the fabrication cost and reduce the reproducibility of a sensor. Thus, a simple yet reliable and cost-effective glucose sensing system is much desired. Inspired by the glucose oxidation mechanism of copper-based nanomaterials, we developed a series of highly sensitive electrochemical glucose sensors using micromol level Cu2+ ions as an electrocatalyst. High sensitivities are achieved on various carbon-based electrodes (GCE: 614 mA M−1 cm−2; activated carbon: 1627 mA M−1 cm−2; carbon paper: 2149 mA M−1 cm−2; graphite powder: 1695 mA M−1 cm−2, and functionalized multi-walled carbon nanotube: 1842 mA M−1 cm−2). With short response time (<2 s), large linear range (0.02 μM–2.5 mM and 2.5–8.0 mM), high stability, and excellent tolerance to interference, Cu ion-based sensor was also validated for testing glucose level in real blood samples. Further studies show that carbon support (e.g., MWCNT-COOH) can be doped with nanomolar level Cu2+ to produce a practical solid electrode with an ultra-high sensitivity of 1732 mA M−1 cm−2, retaining the advantage of atomic efficiency. This work provides a new route to the rational design of simple, cheap, and highly effective electrochemical glucose sensors.
KW - Activated carbon
KW - Carbon paper
KW - Copper ion
KW - Glucose
KW - Graphite
KW - MWCNT
KW - Sensor
UR - http://www.scopus.com/inward/record.url?scp=85056768181&partnerID=8YFLogxK
U2 - 10.1016/j.snb.2018.10.164
DO - 10.1016/j.snb.2018.10.164
M3 - 文章
AN - SCOPUS:85056768181
SN - 0925-4005
VL - 282
SP - 187
EP - 196
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
ER -