Type VI secretion regulation: Crosstalk and intracellular communication

Ka Yin Leung*, Bupe A. Siame, Heather Snowball, Yu Keung Mok

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations


Pathogens use type VI secretion systems (T6SSs) to transport proteins into the environment or host cells in response to external stimuli. T6SSs are tightly regulated together with other virulence determinants such as type III secretion systems, quorum sensing (QS), and flagella synthesis. Five pathogens (Salmonella enterica, Edwardsiella tarda, Aeromonas hydrophila, Vibrio cholerae, and Pseudomonas aeruginosa) are examined for crosstalk proteins (global regulators) that connect T6SSs to other virulence determinants. Common transcriptional regulators (TRs) include two component systems (i.e. PhoPQ), σ54 and σ54-dependent TRs (i.e. VasH), and QS regulators. Greater understanding of this integral communication network will define what is essential for bacterial pathogenesis.

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalCurrent Opinion in Microbiology
Issue number1
StatePublished - Feb 2011
Externally publishedYes


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