Type VI secretion regulation: Crosstalk and intracellular communication

Ka Yin Leung; Bupe A. Siame; Heather Snowball; Yu Keung Mok

doi:10.1016/j.mib.2010.09.017

Type VI secretion regulation: Crosstalk and intracellular communication

Ka Yin Leung^*, Bupe A. Siame, Heather Snowball, Yu Keung Mok

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Abstract

Pathogens use type VI secretion systems (T6SSs) to transport proteins into the environment or host cells in response to external stimuli. T6SSs are tightly regulated together with other virulence determinants such as type III secretion systems, quorum sensing (QS), and flagella synthesis. Five pathogens (Salmonella enterica, Edwardsiella tarda, Aeromonas hydrophila, Vibrio cholerae, and Pseudomonas aeruginosa) are examined for crosstalk proteins (global regulators) that connect T6SSs to other virulence determinants. Common transcriptional regulators (TRs) include two component systems (i.e. PhoPQ), σ⁵⁴ and σ⁵⁴-dependent TRs (i.e. VasH), and QS regulators. Greater understanding of this integral communication network will define what is essential for bacterial pathogenesis.

Original language	English
Pages (from-to)	9-15
Number of pages	7
Journal	Current Opinion in Microbiology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.mib.2010.09.017
State	Published - Feb 2011
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.mib.2010.09.017

Cite this

@article{2da0cc1d532c4041a47cd9254f63a14e,

title = "Type VI secretion regulation: Crosstalk and intracellular communication",

abstract = "Pathogens use type VI secretion systems (T6SSs) to transport proteins into the environment or host cells in response to external stimuli. T6SSs are tightly regulated together with other virulence determinants such as type III secretion systems, quorum sensing (QS), and flagella synthesis. Five pathogens (Salmonella enterica, Edwardsiella tarda, Aeromonas hydrophila, Vibrio cholerae, and Pseudomonas aeruginosa) are examined for crosstalk proteins (global regulators) that connect T6SSs to other virulence determinants. Common transcriptional regulators (TRs) include two component systems (i.e. PhoPQ), σ54 and σ54-dependent TRs (i.e. VasH), and QS regulators. Greater understanding of this integral communication network will define what is essential for bacterial pathogenesis.",

author = "Leung, {Ka Yin} and Siame, {Bupe A.} and Heather Snowball and Mok, {Yu Keung}",

note = "Funding Information: Our thanks go to Drs. Jun Zheng, Hong Bing Yu, and Ilan Rosenshine for critically reviewing the manuscript. Work in the authors{\textquoteright} laboratories was supported by a Natural Science and Engineering Research Council (NSERC) Discovery Grant ( 372373-2010 ) and a Trinity Western University Startup Grant ( 0488 ) to K.Y.L., a Biomedical Research Council (BMRC) grant from the Agency for Science Technology and Research (A*STAR), Singapore to Y.K.M. (07/1/21/19/495). ",

year = "2011",

month = feb,

doi = "10.1016/j.mib.2010.09.017",

language = "英语",

volume = "14",

pages = "9--15",

journal = "Current Opinion in Microbiology",

issn = "1369-5274",

publisher = "Elsevier Ltd.",

number = "1",

}

TY - JOUR

T1 - Type VI secretion regulation

T2 - Crosstalk and intracellular communication

AU - Leung, Ka Yin

AU - Siame, Bupe A.

AU - Snowball, Heather

AU - Mok, Yu Keung

N1 - Funding Information: Our thanks go to Drs. Jun Zheng, Hong Bing Yu, and Ilan Rosenshine for critically reviewing the manuscript. Work in the authors’ laboratories was supported by a Natural Science and Engineering Research Council (NSERC) Discovery Grant ( 372373-2010 ) and a Trinity Western University Startup Grant ( 0488 ) to K.Y.L., a Biomedical Research Council (BMRC) grant from the Agency for Science Technology and Research (A*STAR), Singapore to Y.K.M. (07/1/21/19/495).

PY - 2011/2

Y1 - 2011/2

N2 - Pathogens use type VI secretion systems (T6SSs) to transport proteins into the environment or host cells in response to external stimuli. T6SSs are tightly regulated together with other virulence determinants such as type III secretion systems, quorum sensing (QS), and flagella synthesis. Five pathogens (Salmonella enterica, Edwardsiella tarda, Aeromonas hydrophila, Vibrio cholerae, and Pseudomonas aeruginosa) are examined for crosstalk proteins (global regulators) that connect T6SSs to other virulence determinants. Common transcriptional regulators (TRs) include two component systems (i.e. PhoPQ), σ54 and σ54-dependent TRs (i.e. VasH), and QS regulators. Greater understanding of this integral communication network will define what is essential for bacterial pathogenesis.

AB - Pathogens use type VI secretion systems (T6SSs) to transport proteins into the environment or host cells in response to external stimuli. T6SSs are tightly regulated together with other virulence determinants such as type III secretion systems, quorum sensing (QS), and flagella synthesis. Five pathogens (Salmonella enterica, Edwardsiella tarda, Aeromonas hydrophila, Vibrio cholerae, and Pseudomonas aeruginosa) are examined for crosstalk proteins (global regulators) that connect T6SSs to other virulence determinants. Common transcriptional regulators (TRs) include two component systems (i.e. PhoPQ), σ54 and σ54-dependent TRs (i.e. VasH), and QS regulators. Greater understanding of this integral communication network will define what is essential for bacterial pathogenesis.

UR - http://www.scopus.com/inward/record.url?scp=79551688546&partnerID=8YFLogxK

U2 - 10.1016/j.mib.2010.09.017

DO - 10.1016/j.mib.2010.09.017

M3 - 文献综述

C2 - 20971679

AN - SCOPUS:79551688546

SN - 1369-5274

VL - 14

SP - 9

EP - 15

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

IS - 1

ER -

Type VI secretion regulation: Crosstalk and intracellular communication

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this