The I1307K Adenomatous Polyposis Coli Gene Variant Does Not Contribute in the Assessment of the Risk for Colorectal Cancer in Ashkenazi Jews

Hana Strul; Erez Barenboim; Moshe Leshno; Myra Gartner; Revital Kariv; Eli Aljadeff; Yonathan Aljadeff; Dina Kazanov; Ludmila Strier; Andre Keidar; Yehudit Knaani; Yaara Degani; Limor Alon-Baron; Hadas Sobol-Dvory; Zamir Halpern; Nadir Arber

The I1307K Adenomatous Polyposis Coli Gene Variant Does Not Contribute in the Assessment of the Risk for Colorectal Cancer in Ashkenazi Jews

Hana Strul, Erez Barenboim, Moshe Leshno, Myra Gartner, Revital Kariv, Eli Aljadeff, Yonathan Aljadeff, Dina Kazanov, Ludmila Strier, Andre Keidar, Yehudit Knaani, Yaara Degani, Limor Alon-Baron, Hadas Sobol-Dvory, Zamir Halpern, Nadir Arber^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Ashkenazi Jews with the I1307K adenomatous polyposis coli gene variant were suggested to confer a higher risk for colorectal cancer (CRC). We assessed the clinical importance of this polymorphism in Israeli Jews at average and elevated risk for CRC. Among 1370 consecutive subjects that were examined, 975 Ashkenazi Jews were stratified into those at average risk (no personal or family history of colorectal neoplasia) and those at high risk. DNA was obtained from peripheral leukocytes and amplified by PCR, with primers designed to detect the I1307K variant. Overall, I1307K polymorphism was found in 7.1 % (9.1% among Ashkenazi and 1.7% among non-Ashkenazi Jews). The carrier rate was 8.3 and 9.3% in average and high-risk Ashkenazim, respectively (P = 0.65). The overall odds ratio for neoplasia in carriers was 1.43 (95% confidence interval, 0.89-2.30). Age, gender, and the histopathological features of adenomas and cancers did not differ between carriers and noncarriers. No interaction on the CRC risk was found between I1307K variant and lifestyle modifiers (such as cigarette smoking, alcohol consumption, high body mass index, low physical activity, and vitamins/antioxidant intake). The I1307K adenomatous polyposis coli gene variant is not an important marker for increased risk for CRC. It confirms previous reports of a slight nonsignificant increase (OR, 1.4) in the risk of CRC in these carriers. There is no interaction effect on the risk of colorectal neoplasia between the I1307K variant and various lifestyle risk factors. The usual recommended screening and surveillance strategies should be used for carriers of this polymorphism.

Original language	English
Pages (from-to)	1012-1015
Number of pages	4
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	12
Issue number	10
State	Published - Oct 2003
Externally published	Yes

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Strul, H., Barenboim, E., Leshno, M., Gartner, M., Kariv, R., Aljadeff, E., Aljadeff, Y., Kazanov, D., Strier, L., Keidar, A., Knaani, Y., Degani, Y., Alon-Baron, L., Sobol-Dvory, H., Halpern, Z., & Arber, N. (2003). The I1307K Adenomatous Polyposis Coli Gene Variant Does Not Contribute in the Assessment of the Risk for Colorectal Cancer in Ashkenazi Jews. Cancer Epidemiology Biomarkers and Prevention, 12(10), 1012-1015.

@article{56e5a78e1eaa41dd84c4726f0a9fbc4b,

title = "The I1307K Adenomatous Polyposis Coli Gene Variant Does Not Contribute in the Assessment of the Risk for Colorectal Cancer in Ashkenazi Jews",

abstract = "Ashkenazi Jews with the I1307K adenomatous polyposis coli gene variant were suggested to confer a higher risk for colorectal cancer (CRC). We assessed the clinical importance of this polymorphism in Israeli Jews at average and elevated risk for CRC. Among 1370 consecutive subjects that were examined, 975 Ashkenazi Jews were stratified into those at average risk (no personal or family history of colorectal neoplasia) and those at high risk. DNA was obtained from peripheral leukocytes and amplified by PCR, with primers designed to detect the I1307K variant. Overall, I1307K polymorphism was found in 7.1 % (9.1% among Ashkenazi and 1.7% among non-Ashkenazi Jews). The carrier rate was 8.3 and 9.3% in average and high-risk Ashkenazim, respectively (P = 0.65). The overall odds ratio for neoplasia in carriers was 1.43 (95% confidence interval, 0.89-2.30). Age, gender, and the histopathological features of adenomas and cancers did not differ between carriers and noncarriers. No interaction on the CRC risk was found between I1307K variant and lifestyle modifiers (such as cigarette smoking, alcohol consumption, high body mass index, low physical activity, and vitamins/antioxidant intake). The I1307K adenomatous polyposis coli gene variant is not an important marker for increased risk for CRC. It confirms previous reports of a slight nonsignificant increase (OR, 1.4) in the risk of CRC in these carriers. There is no interaction effect on the risk of colorectal neoplasia between the I1307K variant and various lifestyle risk factors. The usual recommended screening and surveillance strategies should be used for carriers of this polymorphism.",

author = "Hana Strul and Erez Barenboim and Moshe Leshno and Myra Gartner and Revital Kariv and Eli Aljadeff and Yonathan Aljadeff and Dina Kazanov and Ludmila Strier and Andre Keidar and Yehudit Knaani and Yaara Degani and Limor Alon-Baron and Hadas Sobol-Dvory and Zamir Halpern and Nadir Arber",

year = "2003",

month = oct,

language = "英语",

volume = "12",

pages = "1012--1015",

journal = "Cancer Epidemiology Biomarkers and Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "10",

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Strul, H, Barenboim, E, Leshno, M, Gartner, M, Kariv, R, Aljadeff, E, Aljadeff, Y, Kazanov, D, Strier, L, Keidar, A, Knaani, Y, Degani, Y, Alon-Baron, L, Sobol-Dvory, H, Halpern, Z & Arber, N 2003, 'The I1307K Adenomatous Polyposis Coli Gene Variant Does Not Contribute in the Assessment of the Risk for Colorectal Cancer in Ashkenazi Jews', Cancer Epidemiology Biomarkers and Prevention, vol. 12, no. 10, pp. 1012-1015.

TY - JOUR

T1 - The I1307K Adenomatous Polyposis Coli Gene Variant Does Not Contribute in the Assessment of the Risk for Colorectal Cancer in Ashkenazi Jews

AU - Strul, Hana

AU - Barenboim, Erez

AU - Leshno, Moshe

AU - Gartner, Myra

AU - Kariv, Revital

AU - Aljadeff, Eli

AU - Aljadeff, Yonathan

AU - Kazanov, Dina

AU - Strier, Ludmila

AU - Keidar, Andre

AU - Knaani, Yehudit

AU - Degani, Yaara

AU - Alon-Baron, Limor

AU - Sobol-Dvory, Hadas

AU - Halpern, Zamir

AU - Arber, Nadir

PY - 2003/10

Y1 - 2003/10

N2 - Ashkenazi Jews with the I1307K adenomatous polyposis coli gene variant were suggested to confer a higher risk for colorectal cancer (CRC). We assessed the clinical importance of this polymorphism in Israeli Jews at average and elevated risk for CRC. Among 1370 consecutive subjects that were examined, 975 Ashkenazi Jews were stratified into those at average risk (no personal or family history of colorectal neoplasia) and those at high risk. DNA was obtained from peripheral leukocytes and amplified by PCR, with primers designed to detect the I1307K variant. Overall, I1307K polymorphism was found in 7.1 % (9.1% among Ashkenazi and 1.7% among non-Ashkenazi Jews). The carrier rate was 8.3 and 9.3% in average and high-risk Ashkenazim, respectively (P = 0.65). The overall odds ratio for neoplasia in carriers was 1.43 (95% confidence interval, 0.89-2.30). Age, gender, and the histopathological features of adenomas and cancers did not differ between carriers and noncarriers. No interaction on the CRC risk was found between I1307K variant and lifestyle modifiers (such as cigarette smoking, alcohol consumption, high body mass index, low physical activity, and vitamins/antioxidant intake). The I1307K adenomatous polyposis coli gene variant is not an important marker for increased risk for CRC. It confirms previous reports of a slight nonsignificant increase (OR, 1.4) in the risk of CRC in these carriers. There is no interaction effect on the risk of colorectal neoplasia between the I1307K variant and various lifestyle risk factors. The usual recommended screening and surveillance strategies should be used for carriers of this polymorphism.

AB - Ashkenazi Jews with the I1307K adenomatous polyposis coli gene variant were suggested to confer a higher risk for colorectal cancer (CRC). We assessed the clinical importance of this polymorphism in Israeli Jews at average and elevated risk for CRC. Among 1370 consecutive subjects that were examined, 975 Ashkenazi Jews were stratified into those at average risk (no personal or family history of colorectal neoplasia) and those at high risk. DNA was obtained from peripheral leukocytes and amplified by PCR, with primers designed to detect the I1307K variant. Overall, I1307K polymorphism was found in 7.1 % (9.1% among Ashkenazi and 1.7% among non-Ashkenazi Jews). The carrier rate was 8.3 and 9.3% in average and high-risk Ashkenazim, respectively (P = 0.65). The overall odds ratio for neoplasia in carriers was 1.43 (95% confidence interval, 0.89-2.30). Age, gender, and the histopathological features of adenomas and cancers did not differ between carriers and noncarriers. No interaction on the CRC risk was found between I1307K variant and lifestyle modifiers (such as cigarette smoking, alcohol consumption, high body mass index, low physical activity, and vitamins/antioxidant intake). The I1307K adenomatous polyposis coli gene variant is not an important marker for increased risk for CRC. It confirms previous reports of a slight nonsignificant increase (OR, 1.4) in the risk of CRC in these carriers. There is no interaction effect on the risk of colorectal neoplasia between the I1307K variant and various lifestyle risk factors. The usual recommended screening and surveillance strategies should be used for carriers of this polymorphism.

UR - http://www.scopus.com/inward/record.url?scp=10744222509&partnerID=8YFLogxK

M3 - 文章

C2 - 14578136

AN - SCOPUS:10744222509

SN - 1055-9965

VL - 12

SP - 1012

EP - 1015

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

IS - 10

ER -

The I1307K Adenomatous Polyposis Coli Gene Variant Does Not Contribute in the Assessment of the Risk for Colorectal Cancer in Ashkenazi Jews

Abstract

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