Synthesis and characterization of ph sensitive core-shell-corona micelles of poly(styrene-block-2-vinylpyridine-block-ethylene oxide) ABC triblock copolymer in aqueous solutions

Bhavesh Bharatiya*, Shin Ichi Yusa, Vinod Aswal, Ludmila Abezgauz, Dganit Danino, Pratap Bahadur

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The coreshellcorona forming ABC triblock copolymer poly(styrene-block-2- vinylpyridine-block-ethylene oxide), PSP2VPPEO, was synthesized using reversible addition fragmentation chain transfer (RAFT) radical polymerization and characterized by NMR and GPC as PS13P2VP62PEO 47. The aggregation behavior in aqueous solution as a function of pH and temperature was studied. Turbidity measurements were used to monitor the effects associated with change in pH. The pH-sensitive P2VP block (insoluble above pH >5) and resultant protonation/deprotonation phenomenon plays decisive role in the aggregation. We found that spherical micelles of considerably low aggregation number form at pH >5. SANS and DLS characterization indicate the micelles' size and spherical shape remained virtually constant in the pH range 1 to 5. The size and shape were further confirmed by cryo-TEM.

Original languageEnglish
Pages (from-to)1227-1233
Number of pages7
JournalBulletin of the Chemical Society of Japan
Volume84
Issue number11
DOIs
StatePublished - 2011
Externally publishedYes

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