Synergistic effects in mixed micellization between natural and synthetic block copolymers

I. Portnaya*, R. Khalfin, E. Kesselman, D. Danino

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

For applications of block copolymer mixtures as potential new nano-vehicles for delivery, understanding the components mixing characteristics are of special interest. In our previous study [1], we showed that interactions between a biological charged diblock-copolymer like protein, beta-casein, and a synthetic uncharged synthetic triblock copolymer, Lutrol F-127, lead to the formation of mixed micelles. Here we report on synergistic effects found in some mixing ratios, and the mixed micellization characteristics, obtained by Isothermal Titration Calorimetry (ITC), Cryogenic-Transmission Electron Microscopy (cryo-TEM), Small-Angle X-Ray Scattering (SAXS) and Dynamic Light Scattering (DLS). At low Lutrol mole fractions we have observed a complicated micellization process characterized by two critical mixed micelles concentrations (CmMC). Positive and negative synergistic effects of Lutrol were revealed.

Original languageEnglish
Title of host publicationTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Pages221-224
Number of pages4
StatePublished - 2011
Externally publishedYes
EventNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 - Boston, MA, United States
Duration: 13 Jun 201116 Jun 2011

Publication series

NameTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Volume3

Conference

ConferenceNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
CountryUnited States
CityBoston, MA
Period13/06/1116/06/11

Keywords

  • Beta-casein
  • Block copolymers
  • CMC
  • Mixed micellization
  • Synergism

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