Surface Wettability of a Natural Rubber Composite under Stretching: A Model to Predict Cell Survival

Rodney Marcelo Do Nascimento*, Jean François Schmitt, Udi Sarig, João Elias Figueiredo Soares Rodrigues, Carlos Pecharromán, Ana Paula Ramos, Pietro Ciancaglini, Fabricio Luiz Faita, Rachid Rahouadj, Antônio Carlos Hernandes, Ivan Helmuth Bechtold

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We report the stress-strain effect of a stretchable natural rubber (NR)-calcium phosphate composite on the surface wettability (SW) using an innovative approach coupling a uniaxial tensile micromachine, goniometer, and microscope. In situ contact angle measurements in real time were performed during mechanical tension. Our results show that SW is guided by the stress-strain relationship with two different characteristics, depending on the static or dynamic experiments. The results evidenced the limits of the classical theory of wetting. Furthermore, based on the mechanically tunable SW of the system associated with the cytocompatibility of the NR composite, we have modeled such a system for application as a cell support. From the experimental surface energy value, our proposed 3D modeling numerical simulation predicted a window of opportunities for cell-NR survival under mechanical stimuli. The presented data and the thermodynamics-based theoretical approach enable not only accurate correlation of SW with mechanical properties of the NR composite but also provide huge potential for future cell supportability in view of tissue engineering.

Original languageEnglish
Pages (from-to)4639-4646
Number of pages8
JournalLangmuir
Volume37
Issue number15
DOIs
StatePublished - 20 Apr 2021

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