Structure and characterisation of hydroxyethylcellulose-silica nanoparticles

Edward D.H. Mansfield, Yash Pandya, Ellina A. Mun, Sarah E. Rogers, Inbal Abutbul-Ionita, Dganit Danino, Adrian C. Williams, Vitaliy V. Khutoryanskiy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Functionalising nanoparticles with polymers has gained much interest in recent years, as it aids colloidal stability and manipulation of surface properties. Here, polymer-coated thiolated silica nanoparticles were synthesised by self-condensation of 3-mercaptopropyltrimethoxysilane in the presence of hydroxyethylcellulose. These nanoparticles were characterised by dynamic light scattering, small angle neutron scattering, Nanoparticle Tracking Analysis, Raman spectroscopy, FT-IR spectroscopy, thermogravimetric analysis, Ellman's assay, transmission electron microscopy and cryo-transmission electron microscopy. It was found that increasing the amount of hydroxyethylcellulose in the reaction mixture increased the nanoparticle size and reduced the number of thiol groups on their surface. Additionally, by utilising small angle neutron scattering and dynamic light scattering, it was demonstrated that higher concentrations of polymer in the reaction mixture (0.5-2% w/v) resulted in the formation of aggregates, whereby several silica nanoparticles are bridged together with macromolecules of hydroxyethylcellulose. A correlation was identified between the aggregate size and number of particles per aggregate based on size discrepancies observed between DLS and SANS measurements. This information makes it possible to control the size of aggregates during a simple one-pot synthesis; a prospect highly desirable in the design of potential drug delivery systems.

Original languageEnglish
Pages (from-to)6471-6478
Number of pages8
JournalRSC Advances
Issue number12
StatePublished - 2018
Externally publishedYes


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