Sonochemical stabilization of ultrafine colloidal biocompatible magnetite nanoparticles using amino acid, l-arginine, for possible bio applications

Sriharsha Theerdhala, Dhirendra Bahadur, Satish Vitta, Nina Perkas, Ziyi Zhong, Aharon Gedanken*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Materials obtained by the synergistic combination of nanotechnology and biomedicine are an important source of drug delivery and other health care related applications. The anchoring of amino acids onto the surface of nano-sized magnetite is one such example. Herein, we report on the binding of a semi-essential amino acid, l-arginine, onto the surface of nano magnetite, creating a stable aqueous suspension by an in situ one-step method using sonochemical synthesis. An ex situ two-step process was also attempted, but was soon discarded owing to the relative short duration of the suspension attributed to increase in particle size and lower extent of binding. The initial concentration of the amino acid was found to play an important role in controlling the particle size and also the binding motif. Lower concentrations of arginine were found to favor the formation of elongated tubular structures, while at higher concentrations, the elongated structures were less prominent and arginine was found to be adsorbed onto the surface of the magnetite. This surface-functionalized nanomagnetite with amino acids could become a promising vehicle for drug delivery.

Original languageEnglish
Pages (from-to)730-737
Number of pages8
JournalUltrasonics Sonochemistry
Volume17
Issue number4
DOIs
StatePublished - Apr 2010
Externally publishedYes

Keywords

  • Amino acid
  • Drug delivery
  • Magnetite
  • Sonochemistry
  • Stable colloidal solution

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