Preparation and properties of magnetic polymer microspheres

Jianmei Wang; Xueying Wang; Yan Li; Hongyu Si; Chengmin Chen; Jianchun Wang; Zongjun Long; Krishnaswamy Nandakumar

doi:10.1016/j.polymer.2020.122569

Preparation and properties of magnetic polymer microspheres

Jianmei Wang^*, Xueying Wang, Yan Li, Hongyu Si, Chengmin Chen, Jianchun Wang, Zongjun Long, Krishnaswamy Nandakumar

^*Corresponding author for this work

Chemical Engineering

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Magnetic particles are widely used in medical diagnosis and treatment owing to their ever-increasing magnetic targeting ability and superparamagnetism. However, small particle size and low magnetic saturation (MS) are disadvantageous for targeted delivery of magnetic particles. In this study, Fe₃O₄@polyvinyl alcohol (PVA) microspheres were prepared by an on-chip droplet microfluidic technology on a polydimethylsiloxane microchip. The morphology and elemental analysis test results demonstrate that Fe₃O₄@PVA microspheres have a uniform particle size and even distribution of Fe₃O₄ nanoparticles on microspheres. The MS reaches 15.43 emu·g⁻¹ when the concentration of Fe₃O₄ is 33.3%, which linearly increases with an increase in the content of Fe₃O₄ in the microspheres. The microscopic observation results of magnetic motion further prove that Fe₃O₄@PVA microspheres maintain good superparamagnetism and drivability. This preparation process is simple, fast, and accurate. Fe₃O₄@PVA microspheres show many potential applications in medical diagnosis and treatment.

Original language	English
Article number	122569
Journal	Polymer
Volume	199
DOIs	https://doi.org/10.1016/j.polymer.2020.122569
State	Published - 11 Jun 2020

Keywords

Droplet microfluidic
Magnetic polymer microsphere
Magnetic saturation
On-chip
Superparamagnetism

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10.1016/j.polymer.2020.122569

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title = "Preparation and properties of magnetic polymer microspheres",

abstract = "Magnetic particles are widely used in medical diagnosis and treatment owing to their ever-increasing magnetic targeting ability and superparamagnetism. However, small particle size and low magnetic saturation (MS) are disadvantageous for targeted delivery of magnetic particles. In this study, Fe3O4@polyvinyl alcohol (PVA) microspheres were prepared by an on-chip droplet microfluidic technology on a polydimethylsiloxane microchip. The morphology and elemental analysis test results demonstrate that Fe3O4@PVA microspheres have a uniform particle size and even distribution of Fe3O4 nanoparticles on microspheres. The MS reaches 15.43 emu·g−1 when the concentration of Fe3O4 is 33.3%, which linearly increases with an increase in the content of Fe3O4 in the microspheres. The microscopic observation results of magnetic motion further prove that Fe3O4@PVA microspheres maintain good superparamagnetism and drivability. This preparation process is simple, fast, and accurate. Fe3O4@PVA microspheres show many potential applications in medical diagnosis and treatment.",

keywords = "Droplet microfluidic, Magnetic polymer microsphere, Magnetic saturation, On-chip, Superparamagnetism",

author = "Jianmei Wang and Xueying Wang and Yan Li and Hongyu Si and Chengmin Chen and Jianchun Wang and Zongjun Long and Krishnaswamy Nandakumar",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = jun,

day = "11",

doi = "10.1016/j.polymer.2020.122569",

language = "英语",

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T1 - Preparation and properties of magnetic polymer microspheres

AU - Wang, Jianmei

AU - Wang, Xueying

AU - Li, Yan

AU - Si, Hongyu

AU - Chen, Chengmin

AU - Wang, Jianchun

AU - Long, Zongjun

AU - Nandakumar, Krishnaswamy

PY - 2020/6/11

Y1 - 2020/6/11

N2 - Magnetic particles are widely used in medical diagnosis and treatment owing to their ever-increasing magnetic targeting ability and superparamagnetism. However, small particle size and low magnetic saturation (MS) are disadvantageous for targeted delivery of magnetic particles. In this study, Fe3O4@polyvinyl alcohol (PVA) microspheres were prepared by an on-chip droplet microfluidic technology on a polydimethylsiloxane microchip. The morphology and elemental analysis test results demonstrate that Fe3O4@PVA microspheres have a uniform particle size and even distribution of Fe3O4 nanoparticles on microspheres. The MS reaches 15.43 emu·g−1 when the concentration of Fe3O4 is 33.3%, which linearly increases with an increase in the content of Fe3O4 in the microspheres. The microscopic observation results of magnetic motion further prove that Fe3O4@PVA microspheres maintain good superparamagnetism and drivability. This preparation process is simple, fast, and accurate. Fe3O4@PVA microspheres show many potential applications in medical diagnosis and treatment.

AB - Magnetic particles are widely used in medical diagnosis and treatment owing to their ever-increasing magnetic targeting ability and superparamagnetism. However, small particle size and low magnetic saturation (MS) are disadvantageous for targeted delivery of magnetic particles. In this study, Fe3O4@polyvinyl alcohol (PVA) microspheres were prepared by an on-chip droplet microfluidic technology on a polydimethylsiloxane microchip. The morphology and elemental analysis test results demonstrate that Fe3O4@PVA microspheres have a uniform particle size and even distribution of Fe3O4 nanoparticles on microspheres. The MS reaches 15.43 emu·g−1 when the concentration of Fe3O4 is 33.3%, which linearly increases with an increase in the content of Fe3O4 in the microspheres. The microscopic observation results of magnetic motion further prove that Fe3O4@PVA microspheres maintain good superparamagnetism and drivability. This preparation process is simple, fast, and accurate. Fe3O4@PVA microspheres show many potential applications in medical diagnosis and treatment.

KW - Droplet microfluidic

KW - Magnetic polymer microsphere

KW - Magnetic saturation

KW - On-chip

KW - Superparamagnetism

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U2 - 10.1016/j.polymer.2020.122569

DO - 10.1016/j.polymer.2020.122569

M3 - 文章

AN - SCOPUS:85084821180

SN - 0032-3861

VL - 199

JO - Polymer

JF - Polymer

M1 - 122569

ER -

Preparation and properties of magnetic polymer microspheres

Abstract

Keywords

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