Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo

Yizhou Dong, J. Robert Dorkin, Weiheng Wang, Philip H. Chang, Matthew J. Webber, Benjamin C. Tang, Junghoon Yang, Inbal Abutbul-Ionita, Dganit Danino, Frank Derosa, Michael Heartlein, Robert Langer, Daniel G. Anderson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Safe and effective delivery is required for siRNA and mRNA-based therapeutics to reach their potential. Here, we report on the development of poly(glycoamidoamine) brush nanoparticles as delivery vehicles for siRNA and mRNA. These polymers were capable of significant delivery of siRNA against FVII and mRNA-encoding erythropoietin (EPO) in mice. Importantly, these nanoparticles were well-tolerated at their effective dose based on analysis of tissue histology, systemic cytokine levels, and liver enzyme chemistry. The polymer brush nanoparticles reported here are promising for therapeutic applications.

Original languageEnglish
Pages (from-to)842-848
Number of pages7
JournalNano Letters
Volume16
Issue number2
DOIs
StatePublished - 10 Feb 2016

Keywords

  • erythropoietin
  • mRNA
  • nanomaterial
  • polymer brush
  • siRNA

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