Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery: In vivo

X. Luo, W. Wang, J. R. Dorkin, O. Veiseh, P. H. Chang, I. Abutbul-Ionita, D. Danino, R. Langer, D. G. Anderson*, Y. Dong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

Original languageEnglish
Pages (from-to)38-40
Number of pages3
JournalBiomaterials Science
Volume5
Issue number1
DOIs
StatePublished - Jan 2017

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