Phenolic content and in vitro antioxidant activity in common beans (Phaseolus vulgaris L.) are not directly related to anti-proliferative activity

TY - JOUR

T1 - Phenolic content and in vitro antioxidant activity in common beans (Phaseolus vulgaris L.) are not directly related to anti-proliferative activity

AU - Yang, Qiong Qiong

AU - Farha, Arakkaveettil Kabeer

AU - Cheng, Lizeng

AU - Kim, Gowoon

AU - Zhang, Tongze

AU - Corke, Harold

N1 - Publisher Copyright: © 2020 Elsevier Ltd

PY - 2020/8

Y1 - 2020/8

N2 - Antioxidant, anti-proliferative activities, and phytochemical profiles of common bean extracts were measured and compared in 10 common bean cultivars. Among the cultivars, a Yunnan cultivar (YN-1) contained the highest total phenolic content (423 mg GAE/100 g dw), total flavonoid content (252 mg CE/100 g dw), total proanthocyanidin content (295 mg CE/100 g dw), and corresponding total antioxidant activity. However, the maximum anti-proliferative activity against colon cancer cell lines (HT29 and HCT116) was shown in a Sichuan cultivar (SC-1) and the maximum anti-proliferative activity against breast cancer cell line (MCF7) was shown in a Heilongjiang cultivar (HJ-1). Antioxidant activity was significantly associated with total phenolics, total flavonoids, and total proanthocyanidins, while anti-proliferative activity of extracts had no correlation with total phenolic contents and in vitro antioxidant activity. In addition, common bean extracts reduced intracellular ROS level. A total of 17 phytochemical compounds were tentatively characterized in the extracts. These results will provide a reference for improving the value of common beans and contribute to the cultivar selection of the common bean cultivars for human health.

AB - Antioxidant, anti-proliferative activities, and phytochemical profiles of common bean extracts were measured and compared in 10 common bean cultivars. Among the cultivars, a Yunnan cultivar (YN-1) contained the highest total phenolic content (423 mg GAE/100 g dw), total flavonoid content (252 mg CE/100 g dw), total proanthocyanidin content (295 mg CE/100 g dw), and corresponding total antioxidant activity. However, the maximum anti-proliferative activity against colon cancer cell lines (HT29 and HCT116) was shown in a Sichuan cultivar (SC-1) and the maximum anti-proliferative activity against breast cancer cell line (MCF7) was shown in a Heilongjiang cultivar (HJ-1). Antioxidant activity was significantly associated with total phenolics, total flavonoids, and total proanthocyanidins, while anti-proliferative activity of extracts had no correlation with total phenolic contents and in vitro antioxidant activity. In addition, common bean extracts reduced intracellular ROS level. A total of 17 phytochemical compounds were tentatively characterized in the extracts. These results will provide a reference for improving the value of common beans and contribute to the cultivar selection of the common bean cultivars for human health.

KW - Anti-proliferative effect

KW - Antioxidant

KW - Phaseolus vulgaris

KW - Polyphenol

UR - http://www.scopus.com/inward/record.url?scp=85086434619&partnerID=8YFLogxK

U2 - 10.1016/j.fbio.2020.100662

DO - 10.1016/j.fbio.2020.100662

M3 - 文章

AN - SCOPUS:85086434619

SN - 2212-4292

VL - 36

JO - Food Bioscience

JF - Food Bioscience

M1 - 100662

ER -