Phenolic content and in vitro antioxidant activity in common beans (Phaseolus vulgaris L.) are not directly related to anti-proliferative activity

Qiong Qiong Yang, Arakkaveettil Kabeer Farha, Lizeng Cheng, Gowoon Kim, Tongze Zhang, Harold Corke*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Antioxidant, anti-proliferative activities, and phytochemical profiles of common bean extracts were measured and compared in 10 common bean cultivars. Among the cultivars, a Yunnan cultivar (YN-1) contained the highest total phenolic content (423 mg GAE/100 g dw), total flavonoid content (252 mg CE/100 g dw), total proanthocyanidin content (295 mg CE/100 g dw), and corresponding total antioxidant activity. However, the maximum anti-proliferative activity against colon cancer cell lines (HT29 and HCT116) was shown in a Sichuan cultivar (SC-1) and the maximum anti-proliferative activity against breast cancer cell line (MCF7) was shown in a Heilongjiang cultivar (HJ-1). Antioxidant activity was significantly associated with total phenolics, total flavonoids, and total proanthocyanidins, while anti-proliferative activity of extracts had no correlation with total phenolic contents and in vitro antioxidant activity. In addition, common bean extracts reduced intracellular ROS level. A total of 17 phytochemical compounds were tentatively characterized in the extracts. These results will provide a reference for improving the value of common beans and contribute to the cultivar selection of the common bean cultivars for human health.

Original languageEnglish
Article number100662
JournalFood Bioscience
Volume36
DOIs
StatePublished - Aug 2020
Externally publishedYes

Keywords

  • Anti-proliferative effect
  • Antioxidant
  • Phaseolus vulgaris
  • Polyphenol

Fingerprint Dive into the research topics of 'Phenolic content and in vitro antioxidant activity in common beans (Phaseolus vulgaris L.) are not directly related to anti-proliferative activity'. Together they form a unique fingerprint.

Cite this