Optimized-Surface Wettability: A New Experimental 3D Modeling Approach Predicting Favorable Biomaterial–Cell Interactions

Rodney Marcelo do Nascimento*, Udi Sarig, Nilson Cristino da Cruz, Vanessa Rafaela de Carvalho, Camille Eyssartier, Larbi Siad, Jean François Ganghoffer, Antônio Carlos Hernandes, Rachid Rahouadj

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Despite several decades of research on biomedical implant materials, the identification of predictive and robust in vitro characteristics of cell support ability and viabilities—as indicators of biocompatibility and future implant-tissue integration—remain elusive. This study addresses the phenomenology of cell–implant interfaces based on experimental, theoretical, and numerical analysis of cell response to functionalized bioceramic coatings of commercial titanium implants, cp-Ti. A variable spectrum of coatings having differing surface wettabilities, with optimized solid tension values, is obtained. Measured values are modeled and correlated to cell support ability and viabilities. The contributions of different surface aspects to cell viability are decoupled, resulting in the identification of the polar component of the surface free energy as a significant and major cell–substrate effector. Furthermore, results of this study and the suggested model establish the thermodynamic interfacial free energy as an omnipotent measure that can be fully correlated to the morphology of an individual cell under numerical simulation matching empirical observations. Collectively, the 3D model reported herein can offer a new generic theoretical framework, using implementable mathematical simulation, toward the objective of rational biomaterial design that can improve next-generation metal and ceramic implants.

Original languageEnglish
Article number1900079
JournalAdvanced Theory and Simulations
Volume2
Issue number7
DOIs
StatePublished - 1 Jul 2019

Keywords

  • bioceramic coatings
  • biomaterials
  • biomaterial–cell interaction
  • biophysical modeling
  • cell morphologies
  • interfacial energies
  • tissue engineering

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