Abstract
Attempts to deal with the problem of detrimental biofilms using nanoparticle technologies have generally focussed on exploiting biocidal approaches. However, it is now recognised that biofilm matrix-components may be targets for the disruption or dispersion of biofilms. Here, we show that the functionalization of gold nanoparticles with the enzyme, proteinase-K (PK) led to both biocidal and matrix disruption effects within Pseudomonas fluorescens biofilms and released cells. This study highlights the potential mechanisms underpinning the properties of Proteinase-K functionalized gold nanoparticles. With the emergence of biocide-resistant biofilm-forming organisms, novel nanoparticle strategies may provide the ideal solution for disrupting and inactivating biofilm cells, thereby minimising the use of biocides or antibiotics.
Original language | English |
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Pages (from-to) | 419-428 |
Number of pages | 10 |
Journal | Journal of Colloid and Interface Science |
Volume | 526 |
DOIs | |
State | Published - 15 Sep 2018 |
Externally published | Yes |
Keywords
- Biofilm
- Enzyme
- Nanoparticle