Milk protein nanocapsules for drug delivery

R. Khalfin*, M. Bachar, D. Danino

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

In the presented work we investigated the possible use of β-casein micelles as a vehicle for delivery of water-insoluble molecules, particularly drugs. Our model drug, celecoxib, was encapsulated in micelles of β-casein. Freeze-dried and resuspended micelles retained their original pre-lyophilized structure, uniform size, and morphology. Small-angle X-ray scattering (SAXS) measurements show a transition from an oblate ellipsoid to a more spherical micelle shape and an increase in the micelle size upon drug loading, and confirm no influence of drying on the dimensions, as also indicated by cryo-TEM. SAXS points to a slight increase in the micelle density after drug loading, confirming mixed micelles formation.

Original languageEnglish
Title of host publicationTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Pages306-309
Number of pages4
StatePublished - 2011
Externally publishedYes
EventNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 - Boston, MA, United States
Duration: 13 Jun 201116 Jun 2011

Publication series

NameTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Volume3

Conference

ConferenceNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
CountryUnited States
CityBoston, MA
Period13/06/1116/06/11

Keywords

  • Beta-casein
  • Drug delivery
  • Micelles
  • Nanoencapsulation

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