Microfluidics-based systems in diagnosis of Alzheimer's disease and biomimetic modeling

Yan Li; Danni Li; Pei Zhao; Krishnaswamy Nandakumar; Liqiu Wang; Youqiang Song

doi:10.3390/MI11090787

Microfluidics-based systems in diagnosis of Alzheimer's disease and biomimetic modeling

Yan Li, Danni Li, Pei Zhao, Krishnaswamy Nandakumar, Liqiu Wang^*, Youqiang Song^*

^*Corresponding author for this work

Chemical Engineering

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Early detection and accurate diagnosis of Alzheimer's disease (AD) is essential for patient care and disease treatment. Microfluidic technology is emerging as an economical and versatile platform in disease detection and diagnosis. It can be conveniently integrated with nanotechnology and/or biological models for biomedical functional and pre-clinical treatment study. These strengths make it advantageous in disease biomarker detection and functional analysis against a wide range of biological backgrounds. This review highlights the recent developments and trends of microfluidic applications in AD research. The first part looks at the principles and methods for AD diagnostic biomarker detection and profiling. The second part discusses how microfluidic chips, especially organ-on-a-chip platforms, could be used as an independent approach and/or integrated with other technologies in AD biomimetic functional analysis.

Original language	English
Article number	787
Journal	Micromachines
Volume	11
Issue number	9
DOIs	https://doi.org/10.3390/MI11090787
State	Published - Sep 2020

Keywords

AD biomarkers
Alzheimer's disease (AD)
Blood-brain barrier (BBB)
Microfluidic chips
Three-dimensional AD model

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10.3390/MI11090787

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title = "Microfluidics-based systems in diagnosis of Alzheimer's disease and biomimetic modeling",

abstract = "Early detection and accurate diagnosis of Alzheimer's disease (AD) is essential for patient care and disease treatment. Microfluidic technology is emerging as an economical and versatile platform in disease detection and diagnosis. It can be conveniently integrated with nanotechnology and/or biological models for biomedical functional and pre-clinical treatment study. These strengths make it advantageous in disease biomarker detection and functional analysis against a wide range of biological backgrounds. This review highlights the recent developments and trends of microfluidic applications in AD research. The first part looks at the principles and methods for AD diagnostic biomarker detection and profiling. The second part discusses how microfluidic chips, especially organ-on-a-chip platforms, could be used as an independent approach and/or integrated with other technologies in AD biomimetic functional analysis.",

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author = "Yan Li and Danni Li and Pei Zhao and Krishnaswamy Nandakumar and Liqiu Wang and Youqiang Song",

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T1 - Microfluidics-based systems in diagnosis of Alzheimer's disease and biomimetic modeling

AU - Li, Yan

AU - Li, Danni

AU - Zhao, Pei

AU - Nandakumar, Krishnaswamy

AU - Wang, Liqiu

AU - Song, Youqiang

PY - 2020/9

Y1 - 2020/9

N2 - Early detection and accurate diagnosis of Alzheimer's disease (AD) is essential for patient care and disease treatment. Microfluidic technology is emerging as an economical and versatile platform in disease detection and diagnosis. It can be conveniently integrated with nanotechnology and/or biological models for biomedical functional and pre-clinical treatment study. These strengths make it advantageous in disease biomarker detection and functional analysis against a wide range of biological backgrounds. This review highlights the recent developments and trends of microfluidic applications in AD research. The first part looks at the principles and methods for AD diagnostic biomarker detection and profiling. The second part discusses how microfluidic chips, especially organ-on-a-chip platforms, could be used as an independent approach and/or integrated with other technologies in AD biomimetic functional analysis.

AB - Early detection and accurate diagnosis of Alzheimer's disease (AD) is essential for patient care and disease treatment. Microfluidic technology is emerging as an economical and versatile platform in disease detection and diagnosis. It can be conveniently integrated with nanotechnology and/or biological models for biomedical functional and pre-clinical treatment study. These strengths make it advantageous in disease biomarker detection and functional analysis against a wide range of biological backgrounds. This review highlights the recent developments and trends of microfluidic applications in AD research. The first part looks at the principles and methods for AD diagnostic biomarker detection and profiling. The second part discusses how microfluidic chips, especially organ-on-a-chip platforms, could be used as an independent approach and/or integrated with other technologies in AD biomimetic functional analysis.

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KW - Alzheimer's disease (AD)

KW - Blood-brain barrier (BBB)

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U2 - 10.3390/MI11090787

DO - 10.3390/MI11090787

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JO - Micromachines

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Microfluidics-based systems in diagnosis of Alzheimer's disease and biomimetic modeling

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Keywords

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