Microbial Coculture for Flavonoid Synthesis

Peng Xu*, Monireh Marsafari, Jian Zha, Mattheos Koffas

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

40 Scopus citations


Flavonoids are plant-derived natural products with human health-promoting benefits. The modularity and complexity of the flavonoid biosynthetic pathway allow us to leverage the metabolic characteristics of distinct microbial hosts and install structural functionalities beyond what monocultures can achieve. We discuss the promising future of applying microbial cocultures to improve the cost-efficiency and diversity of flavonoid biosynthesis.

Original languageEnglish
Pages (from-to)686-688
Number of pages3
JournalTrends in Biotechnology
Issue number7
StatePublished - Jul 2020
Externally publishedYes


  • flavonoids
  • host selection
  • microbial coculture
  • pathway efficiency
  • population dynamics
  • structural diversity


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