Issues and technologies leading to a new bio-artificial liver with microencapsulated hepatocytes

Ser Mien Chia*, Yi Zhou, Tao Sun, Hai Quan Mao, Kam W. Leong, Jia Ping Chen, Hanry Yu

*Corresponding author for this work

Research output: Contribution to conferencePaperpeer-review

Abstract

The efforts being made to address a number of relevant issues and to develop the means for a new bio-artificial liver based on the microcapsules are discussed. The four classes of configurable microcapsules with controllable mechanical stabilities, and one class of the fragile microcapsules have been successfully applied to culture. To scale up the production of encapsulating hepatocytes in such ultra-thin microcapsules, the relationship between the physical, and chemical parameters of the biomaterials, and the microcapsules. An electro-hydrodynamic method, and a device are also developed of forming the microcapsules with well-controlled diameters, and shell thickness.

Original languageEnglish
Pages71
Number of pages1
StatePublished - 2002
Externally publishedYes
EventThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products - Atlanta, GA, United States
Duration: 13 Oct 200216 Oct 2002

Conference

ConferenceThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products
CountryUnited States
CityAtlanta, GA
Period13/10/0216/10/02

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