Iridium(III)-Catalyzed CH Amidation of Arylphosphoryls Leading to a P-Stereogenic Center

Donghyeon Gwon, Donggun Lee, Jiyu Kim, Sehoon Park*, Sukbok Chang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Direct CH amidation of arylphosphoryl compounds has been developed by using an IrIIIcatalyst system under mild conditions. A wide range of substrates could be employed with high functional-group tolerance. This procedure was successfully applied for the first time to the asymmetric reaction giving rise to a P-chirogenic center with a high diastereomeric ratio of up to 19:1 (90 % de).

Original languageEnglish
Pages (from-to)12421-12425
Number of pages5
JournalChemistry - A European Journal
Issue number39
StatePublished - 22 Sep 2014
Externally publishedYes


  • CH functionalization
  • asymmetric induction
  • chirality
  • iridium catalysis
  • phosphine oxides


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