Formation of celecoxib nanoparticles from volatile microemulsions

Katrin Margulis-Goshen; Ellina Kesselman; Dganit Danino; Shlomo Magdassi

doi:10.1016/j.ijpharm.2010.04.012

Formation of celecoxib nanoparticles from volatile microemulsions

Katrin Margulis-Goshen, Ellina Kesselman, Dganit Danino, Shlomo Magdassi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

A new composition of a fully water-dilutable microemulsion system stabilized by natural surfactants is presented as a template for preparation of celecoxib nanoparticles. Nanoparticles are obtained as a dry powder upon rapid conversion of microemulsion droplets with dissolved celecoxib into nanoparticles, followed by evaporation of all the liquid in a spray dryer. The resultant powder is easily re-dispersible in water to form a clear, transparent dispersion. The celecoxib nanoparticles are amorphous and their average size in the dispersion is 17. nm, in agreement with cryo-TEM results and concentration measurements after filtration. As a result of the nanometric size and amorphous state, about 10-fold increase in dissolution of the powder was obtained, compared to that for particulate celecoxib in the presence of surfactants.

Original language	English
Pages (from-to)	231-238
Number of pages	8
Journal	International Journal of Pharmaceutics
Volume	393
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2010.04.012
State	Published - Jun 2010
Externally published	Yes

Keywords

Celecoxib
Evaporation
Microemulsion
Organic nanoparticles
Poorly soluble drug

Access to Document

10.1016/j.ijpharm.2010.04.012

Cite this

@article{e45ac44a3dd549f0a21f9a9321e522f4,

title = "Formation of celecoxib nanoparticles from volatile microemulsions",

abstract = "A new composition of a fully water-dilutable microemulsion system stabilized by natural surfactants is presented as a template for preparation of celecoxib nanoparticles. Nanoparticles are obtained as a dry powder upon rapid conversion of microemulsion droplets with dissolved celecoxib into nanoparticles, followed by evaporation of all the liquid in a spray dryer. The resultant powder is easily re-dispersible in water to form a clear, transparent dispersion. The celecoxib nanoparticles are amorphous and their average size in the dispersion is 17. nm, in agreement with cryo-TEM results and concentration measurements after filtration. As a result of the nanometric size and amorphous state, about 10-fold increase in dissolution of the powder was obtained, compared to that for particulate celecoxib in the presence of surfactants.",

keywords = "Celecoxib, Evaporation, Microemulsion, Organic nanoparticles, Poorly soluble drug",

author = "Katrin Margulis-Goshen and Ellina Kesselman and Dganit Danino and Shlomo Magdassi",

year = "2010",

month = jun,

doi = "10.1016/j.ijpharm.2010.04.012",

language = "英语",

volume = "393",

pages = "231--238",

journal = "International Journal of Pharmaceutics",

issn = "0378-5173",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Formation of celecoxib nanoparticles from volatile microemulsions

AU - Margulis-Goshen, Katrin

AU - Kesselman, Ellina

AU - Danino, Dganit

AU - Magdassi, Shlomo

PY - 2010/6

Y1 - 2010/6

N2 - A new composition of a fully water-dilutable microemulsion system stabilized by natural surfactants is presented as a template for preparation of celecoxib nanoparticles. Nanoparticles are obtained as a dry powder upon rapid conversion of microemulsion droplets with dissolved celecoxib into nanoparticles, followed by evaporation of all the liquid in a spray dryer. The resultant powder is easily re-dispersible in water to form a clear, transparent dispersion. The celecoxib nanoparticles are amorphous and their average size in the dispersion is 17. nm, in agreement with cryo-TEM results and concentration measurements after filtration. As a result of the nanometric size and amorphous state, about 10-fold increase in dissolution of the powder was obtained, compared to that for particulate celecoxib in the presence of surfactants.

AB - A new composition of a fully water-dilutable microemulsion system stabilized by natural surfactants is presented as a template for preparation of celecoxib nanoparticles. Nanoparticles are obtained as a dry powder upon rapid conversion of microemulsion droplets with dissolved celecoxib into nanoparticles, followed by evaporation of all the liquid in a spray dryer. The resultant powder is easily re-dispersible in water to form a clear, transparent dispersion. The celecoxib nanoparticles are amorphous and their average size in the dispersion is 17. nm, in agreement with cryo-TEM results and concentration measurements after filtration. As a result of the nanometric size and amorphous state, about 10-fold increase in dissolution of the powder was obtained, compared to that for particulate celecoxib in the presence of surfactants.

KW - Celecoxib

KW - Evaporation

KW - Microemulsion

KW - Organic nanoparticles

KW - Poorly soluble drug

UR - http://www.scopus.com/inward/record.url?scp=77953357896&partnerID=8YFLogxK

U2 - 10.1016/j.ijpharm.2010.04.012

DO - 10.1016/j.ijpharm.2010.04.012

M3 - 文章

C2 - 20403417

AN - SCOPUS:77953357896

SN - 0378-5173

VL - 393

SP - 231

EP - 238

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Formation of celecoxib nanoparticles from volatile microemulsions

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this