TY - JOUR
T1 - Fast analysis of narcotic drugs by optical chemical imaging
AU - Fisher, Michal
AU - Bulatov, Vallery
AU - Schechter, Israel
N1 - Funding Information:
This study was supported, in part, by the Mitchell Entrepreneurial Award and by The James Franck Program in Laser Matter Interaction.
Funding Information:
V.B. is grateful for financial support by Ministry of Absorption for new immigrant scientists.
PY - 2003/5
Y1 - 2003/5
N2 - A new technique is proposed for fast detection, identification and imaging of narcotic drugs in their solid phase. This technique, which requires only a tiny sample of a few microns, is based on microscopic chemical imaging. Minor sample preparation is required, and results are obtained within seconds. As far as we know, this is the most sensitive detection system available today for solid drugs. The technique can be applied for fast analysis of minute drug residues, and therefore is of considerable importance for forensic applications. It is shown that identification of drug traces in realistic matrixes is possible. Two main methods were applied in this study for detection of drugs and drug derivatives. The first method was based on direct detection and chemical imaging of the auto-fluorescence of the analyzed drugs. This method is applicable when the analyzed drug emits fluorescence under the experiment conditions, such as lysergic acid diethylamide (known as LSD). The second method was used for obtaining chemical imaging of drugs that do not fluoresce under the experiment conditions. In these cases fluorescent labeling dyes were applied to the examined samples (including the drug and the matrix). Both methods are simple and rapid, and require minor or no sample preparation at all. Detection limits are very low in the picogram range.
AB - A new technique is proposed for fast detection, identification and imaging of narcotic drugs in their solid phase. This technique, which requires only a tiny sample of a few microns, is based on microscopic chemical imaging. Minor sample preparation is required, and results are obtained within seconds. As far as we know, this is the most sensitive detection system available today for solid drugs. The technique can be applied for fast analysis of minute drug residues, and therefore is of considerable importance for forensic applications. It is shown that identification of drug traces in realistic matrixes is possible. Two main methods were applied in this study for detection of drugs and drug derivatives. The first method was based on direct detection and chemical imaging of the auto-fluorescence of the analyzed drugs. This method is applicable when the analyzed drug emits fluorescence under the experiment conditions, such as lysergic acid diethylamide (known as LSD). The second method was used for obtaining chemical imaging of drugs that do not fluoresce under the experiment conditions. In these cases fluorescent labeling dyes were applied to the examined samples (including the drug and the matrix). Both methods are simple and rapid, and require minor or no sample preparation at all. Detection limits are very low in the picogram range.
KW - Chemical imaging
KW - Drug
KW - Fluorescence
UR - http://www.scopus.com/inward/record.url?scp=0037402328&partnerID=8YFLogxK
U2 - 10.1016/S0022-2313(02)00489-1
DO - 10.1016/S0022-2313(02)00489-1
M3 - 会议文章
AN - SCOPUS:0037402328
VL - 102-103
SP - 194
EP - 200
JO - Journal of Luminescence
JF - Journal of Luminescence
SN - 0022-2313
IS - SPEC
Y2 - 24 August 2002 through 29 August 2002
ER -