Fabrication of high specificity hollow mesoporous silica nanoparticles assisted by Eudragit for targeted drug delivery

Xiaodong She, Lijue Chen, Leonora Velleman, Chengpeng Li, Haijin Zhu, Canzhong He, Tao Wang, Sarah Shigdar, Wei Duan*, Lingxue Kong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Hollow mesoporous silica nanoparticles (HMSNs) are one of the most promising carriers for effective drug delivery due to their large surface area, high volume for drug loading and excellent biocompatibility. However, the non-ionic surfactant templated HMSNs often have a broad size distribution and a defective mesoporous structure because of the difficulties involved in controlling the formation and organization of micelles for the growth of silica framework. In this paper, a novel "Eudragit assisted" strategy has been developed to fabricate HMSNs by utilising the Eudragit nanoparticles as cores and to assist in the self-assembly of micelle organisation. Highly dispersed mesoporous silica spheres with intact hollow interiors and through pores on the shell were fabricated. The HMSNs have a high surface area (670m2/g), small diameter (120nm) and uniform pore size (2.5nm) that facilitated the effective encapsulation of 5-fluorouracil within HMSNs, achieving a high loading capacity of 194.5mg(5-FU)/g(HMSNs). The HMSNs were non-cytotoxic to colorectal cancer cells SW480 and can be bioconjugated with Epidermal Growth Factor (EGF) for efficient and specific cell internalization. The high specificity and excellent targeting performance of EGF grafted HMSNs have demonstrated that they can become potential intracellular drug delivery vehicles for colorectal cancers via EGF-EGFR interaction.

Original languageEnglish
Pages (from-to)151-160
Number of pages10
JournalJournal of Colloid and Interface Science
StatePublished - 1 May 2015
Externally publishedYes


  • Eudragit assisted synthesis
  • Hollow mesoporous silica nanoparticles
  • Specificity
  • Targeted delivery


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